| 易庆川 梁国庆 周永彬 范凤霞 周天明.喉癌部分切除术与仙璐贝药物联用对喉癌患者治疗效果的研究[J].,2015,15(18):3526-3529 |
| 喉癌部分切除术与仙璐贝药物联用对喉癌患者治疗效果的研究 |
| Research on Efficacy of Partial Laryngectomy Combined with Sinupret Drugson Patients with Laryngocarcinoma |
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| DOI： |
| 中文关键词: 喉癌 部分切除术 仙璐贝 肺部感染 影响分析 |
| 英文关键词: Laryngocarcinoma Partial resection Sinupret Pulmonary infection Impact analysis |
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| 中文摘要: |
| 目的：研究喉癌部分切除术（Partial laryngectomy，PL）与仙璐贝药物联用对患者肺部感染的影响。方法：选择2008 年3 月到
2013 年3月我院实施PL术式的102 例患者，以数字法随机分成观察组（51 例）及对照组（51例）。对照组予以常规抗生素及鼻饲
饮食，并经雾化吸入等方案治疗；观察组在此基础上另以鼻饲仙璐贝滴剂治疗。治疗10d 后，对比两组临床疗效，以及术后肺部感
染的情况。随访6个月，比较两组声学参数情况。结果：观察组的疗效显著高于对照组，差异有统计学意义（P＜0.05）。观察组与对
照组在基频微扰、振幅微扰以及声门噪声值（Normalized noise value，NNE）等方面对比，差异均无统计学意义（均P＞0.05）。观察
组共计5 例患者在治疗过程中产生肺部感染，占比9.80%，显著少于对照组的15 例，占比29.41%，差异有统计学意义（P＜0.05）。
结论：PL手术联合仙璐贝药物治疗喉癌患者疗效显著，可减少肺部感染，值得临床推广。 |
| 英文摘要: |
| Objective:To research the efficacy of partial laryngectomy combined with sinupret drugs on patients with
laryngocarcinoma.Methods:102 cases of patients with laryngocarcinoma who were treated with PL surgery in our hospital from March
2008 to March 2013 were chosen and randomly divided into observation group (51 cases) and control group (51 cases). The control
group received antibiotics and nasal feeding, inhalation therapy and other programs, while the observation group was treated with
sinupret drugs besides treatment of the control group. The clinical efficacy and postoperative pulmonary infection after 10 days of
treatment were compared, and after six months of follow-up, the acoustic parameters were compared.Results:The effect of the
observation group was significantly higher than that of control group, and the difference was statistically significant (P<0.05). The
difference in Jitter, shimmer and normalized noise value (NNE) between observation group and control group were not statistically
significant (P> 0.05). There were 5 cases of pulmonary infection in the observation group, which accounted for 9.80%, and was
significantly lower than that in the control group (15 cases, accounting for 29.41% )(P<0.05).Conclusion:PL operation combined with
Sinupret is effective in treatment of laryngeal cancer patients, can reduce pulmonary infection, and is worthy of recommendation. |
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