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目的：探讨血浆同型半胱氨酸（Hcy）、血浆纤维蛋白原（FIB）及超敏C反应蛋白（hs-CRP）水平与脑梗死严重程度及复发的关系。方法：回顾性分析本院收治的138 例急性脑梗死患者的临床资料，应用神经功能缺损程度量表对患者脑梗死程度进行评定，监测血浆Hcy、FIB、hs-CRP水平，随访1 年，分析以上各指标水平与脑梗死严重程度及复发的关系。结果：轻度、中度和重度脑梗死患者Hcy、FIB 及hs-CRP 水平比较差异均有统计学意义（P<0.05）；严重程度与Hcy、FIB 及hs-CRP 水平呈正相关性（r=0.51、 0.43、0.39，P<0.05）；复发者FIB 及hs-CRP 水平均显著高于未复发者，比较差异有统计学意义（P<0.05）。结论：血浆Hcy、FIB 及 hs-CRP水平越高脑梗死越严重，且脑梗死复发患者FIB 及hs-CRP 的水平显著上升，临床应紧密检测指标，尽早治疗以防止病情进一步恶化。

英文摘要:

Objective:To investigate the correlation between plasma homocysteine (Hcy), plasma fibrinogen (FIB) and high sensitive C reactive protein (hs-CRP) levels with the severity of cerebral infarction and recurrence.Methods:Clinical data of 138 cases of patients with acute cerebral infarction were retrospectively analyzed in our hospital. The extent of cerebral infarction was evaluated by the neural function defect degree scale, surveyed the levels of Hcy, FIB, hs-CRP. Follow-up for 1 year, analyzed the correlation between above indexes and the severity of cerebral infarction and recurrence.Results:There was a significant difference in Hcy, FIB and hs-CRP levels among mild, moderate and severe cerebral infarction patients (P<0.05), the severity was associated positively with Hcy, FIB and hs-CRP (r=0.51, 0.43, 0.39, P<0.05); FIB and hs-CRP levels in the recurrence group were higher than the non recurrent group, there was a significant difference (P<0.05).Conclusion:Plasma Hcy, FIB and hs-CRP level is higher, the cerebral infarction is more serious, and the recurrence of cerebral infarction patients with FIB and hs-CRP level increased significantly. We should closely detecte the indexes, and recieve treatment as soon as possible in order to prevent further deterioration.

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