| 曹广超 张凤梅 张兰举 邢立志 李晓云.芪卫颗粒对2型糖尿病大鼠肾脏氧化应激和病理的影响[J].,2015,15(17):3256-3258 |
| 芪卫颗粒对2型糖尿病大鼠肾脏氧化应激和病理的影响 |
| Influence of Qi Wei Particles on Kidney Oxidative Stress andPathology in Type 2 Diabetic Rats |
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| DOI： |
| 中文关键词: 糖尿病 芪卫颗粒 氧化应激 病理 |
| 英文关键词: Diabetes Qi Wei particles Oxidative stress Pathology |
| 基金项目: |
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| 中文摘要: |
| 目的：研究芪卫颗粒对2 型糖尿病大鼠肾脏氧化应激和病理的影响。方法：先诱导2 型糖尿病大鼠模型50 只，按照随机数
字表法将大鼠分为A组和B组，每组25 只，另选取25 只正常鼠为对照组；A 组给予芪卫颗粒，B 组给予a- 硫辛酸，均治疗3个
月，检测3 组血糖（BG）、糖化血红蛋白（HbA1c）、血脂、肾功能指标、超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽氧化物酶
（GSH-Px），并观察肾脏的病理变化。结果：A 组BG、HbA1c 和血脂水平均显著优于B 组，差异有统计学意义（P＜0.05）；A组肾功
能指标与对照组比较无统计学意义（P＞0.05），A 组肾功能指标显著优于B 组，差异有统计学意义（P＜0.05）；A 组SOD、MDA和
GSH-Px 均优于B 组，差异有统计学意义（P＜0.05）；A 组肾小球病理变化显著优于B 组，差异有统计学意义（P＜0.05）。结论：芪
卫颗粒对2 型糖尿病大鼠肾脏氧化应激有一定抑制作用，能改善肾功能和病理。 |
| 英文摘要: |
| Objective:To study the influence of Qi Wei particles on kidney oxidative stress and pathology in type 2 diabetic rats.Methods:50 type 2 diabetic rats’models were first induced and then randomly divided into group A (n=25) and group B(n=25);25
normal rats were selected as control group.Group A was given Qi Wei particles; group B were received a-lipoic acid. Both of the two
groups were treated for 3 months.Blood glucose (BG), glycated hemoglobin (HbA1c), blood lipids, renal function, superoxide dismutase
(SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) of the three groups were detected, and the pathological changes in
kidney were observed.Results:BG, HbA1c and blood lipid levels of group A were significantly better than those of group B, with
statistical significance (P<0.05); Compared with control group,renal function of group A had no statistical significance (P＞0.05), but
much better than that of group B, with statistical significance (P<0.05); SOD, MDA, GSH-Px and glomerular pathological changes of
group A were all significantly better than those of group B, with statistical significance (P<0.05) (P<0.05).Conclusion:Qi Wei particles
has a certain inhibition to renal oxidative stress in type 2 diabetic rats, which can improve their renal function and pathology. |
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