| 饶进 殷莉 林志美 熊萍 苟晓琴.阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨代谢的影响[J].,2015,15(17):3253-3255 |
| 阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨代谢的影响 |
| The Effect of Alendronate in Combination with Chemotherapy on BoneMetabolismin Patients with Multiple Myeloma |
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| DOI： |
| 中文关键词: 阿仑膦酸钠 化疗 多发性骨髓瘤 疗效 |
| 英文关键词: Alendronate Chemotherapy Multiple myeloma Efficacy Chinese Library |
| 基金项目: |
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| 中文摘要: |
| 目的：研究阿仑膦酸钠联合化疗对多发性骨髓瘤患者骨代谢的影响。方法：选取2011 年4 月到2014 年4 月我院收治的多
发性骨髓瘤患者130 例，按照随机数字表法将患者分为研究组和对照组，每组65 例，对照组给予化疗，研究组在对照组的基础上
给予阿仑膦酸钠，比较两组骨特异性碱性磷酸酶（BAP）、骨钙素（OC）、I 型前胶原氨基肽（PINP）、血钙（Ca）、血磷(P)、beta胶原特殊
序列（茁-CTx）以及碱性磷酸酶(ALP)。结果：治疗后研究组OC、PINP和BAP均显著高于治疗前和对照组，比较差异均有统计学意
义（P＜0.05）；治疗后研究组beta-CTx 显著低于治疗前和对照组，比较差异均有统计学意义（P＜0.05）。结论：阿仑膦酸钠联合化疗治
疗多发性骨髓瘤患者能显著改善其的骨代谢，值得临床推广。 |
| 英文摘要: |
| Objective:To study the effect of alendronate in combination with chemotherapy on bone metabolism in patients with
multiple myeloma.Methods:130 cases with multiple myelomawho treated in our hospital from April 2011 to April 2014were selected,
they were divided into the study group and the control group according to a randomnumber table, 65 cases in each group, the patients of
the control group were treated with chemotherapy, the patients of the study group were given alendronate on the basis of the control
group, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), I procollagen amino-peptide (PINP), calcium, phosphorus, beta
collagen special sequences (beta-CTx) and alkaline phosphatase of two groups were compared.Results:After treatment, the OC, PINP and
BAP of the study group were significantly higher than before treatment andthe control group, the difference was statistically significant
(P<0.05); The beta-CTx of the study group were significantly lower than before treatment and the control group, the difference was
statistically significant (P<0.05).Conclusion:Alendronate combination with chemotherapy in treatment of multiple myeloma can
significantly improve bone metabolism. It is worthy of clinical promotion. |
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