| 董铁英 宣奇佳 刘航 马丽 张清媛.多巴胺D2 受体在肿瘤治疗中的研究进展[J].,2015,15(16):3165-3167 |
| 多巴胺D2 受体在肿瘤治疗中的研究进展 |
| Progress of Dopamine D2 Receptor in the Treatment of Carcinoma |
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| DOI： |
| 中文关键词: 多巴胺 D2 受体 肿瘤 |
| 英文关键词: Dopamine D2 receptor Carcinoma |
| 基金项目: |
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| 中文摘要: |
| 多巴胺（Dopamine）（C6H3(OH)2-CH2-CH2-NH2）是人类中枢神经系统的重要儿茶酚胺类神经递质，通过其相应的膜受体而
发挥情绪、饮食、运动、认知及外周血等的调节作用。多巴胺受体属于膜G 蛋白偶联受体家族。目前发现的多巴胺受体有五种，其
中D2 受体基因主要分布于脑部。近年来的研究表明，多巴胺D2 受体对肿瘤细胞具有抑制作用，对肿瘤的药物治疗具有重要意
义。目前，D2 受体激动剂已经成为大多数泌乳素瘤的首选治疗药物。本文通过文献回顾，对多巴胺受体在肿瘤的预后和治疗中的
作用进行综述。 |
| 英文摘要: |
| Dopamine (C6H3 (OH) 2-CH2-CH2-NH2) is the important catecholamine neurotransmitter of human central nervous
system which could regulate the emotion, diet, exercise, cognitive and peripheral blood by its receptors. Dopamine receptors belong to
the membrane G protein coupled receptor family. As so far, five kinds of dopamine receptors have confirmed, in which the mainly
distributed in the brain is D2 receptor gene. Recent researches have shown that the dopamine D2 receptor would play an important role in
tumor prognosis by inhibiting the proliferation of tumor cells. Nowadays, the D2 receptor agonists have become the first choice in the
treatment of prolactinoma. This paper aims to review the research progress of dopamine receptors in the cancers. |
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