| 黄丹 王学东 段钰萍 严海 黄昊.谷氨酰胺对脓毒症患者肠粘膜屏障功能和免疫功能的影响[J].,2015,15(14):2733-2735 |
| 谷氨酰胺对脓毒症患者肠粘膜屏障功能和免疫功能的影响 |
| Effect of Glutamine on Intestinal Mucosal Barrier Function and ImmuneFunction in Septic Patients |
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| DOI： |
| 中文关键词: 谷氨酰胺 脓毒症 肠粘膜 屏障功能 免疫功能 |
| 英文关键词: Glutamine Sepsis Intestinal Mucosa barrier function Immune function |
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| 中文摘要: |
| 目的：研究谷氨酰胺对脓毒症患者肠道黏膜屏障功能和免疫功能的影响。方法：将2012 年10月至2013 年10 本院收治的
40 例脓毒症患者随机分为治疗组和对照组，每组20 例。两组患者均给予常规对症治疗，治疗组在此基础上加用谷氨酰胺治疗，对
照组接受安慰剂治疗。采用分光光度法监测其血清D-乳酸水平，高效液相色谱法监测尿乳果糖/甘露醇(L/M)值。对比两组肠道
黏膜屏障功能和免疫功能指标及ARDS、MODS 发生率。结果：治疗后，治疗组ARDS 和MODS 发生率分别为24.1%，17.2%，均低
于对照组的38.9%，33.3%，两组比较差异均有统计学意义(P＜0.05）；治疗14 d后，治疗组D- 乳酸及尿L/M水平较对照组明显降
低，血清IgG、IgM、CD4+和CD4+/CD8+水平均增高，两组比较差异均有统计学意义(P＜0.05）。结论：谷氨酰胺治疗脓毒性患能明
显改善肠道黏膜屏障功能，促进患者免疫功能和营养状态的提高，同时还能够降低患者肠道细菌、内毒素移位。 |
| 英文摘要: |
| Objective:To study the effect of glutamine on intestinal mucosal barrier function and immune function in septic
patients.Methods:40 cases of sepsis patients who were treated in our hospital from October 2012 to October 2013 were randomly
divided into treatment group and control group, and 20 cases were in each group. Two groups were given conventional symptomatic
treatment, the treatment group received glutamine treatment and the control group received a placebo. The serumD-lactic acid levels was
detected by spectrophotometry,and urinary lactulose / mannitol (L/M) value was detected by High performance liquid chromatography.
Indexes of intestinal mucosal barrier function, immune function and the incidence of ARDS, MODS were compared between two groups.Results:After treatment, the incidence of ARDS, MODS of treatment group were 24.1%, 17.2%, lower than those of the control group
(38.9%, 33.3%), the difference was statistically significant (P<0.05); At 14 days after treatment, the D-lactic acid level and the urinary
L/M level in treatment group were significantly lower than those of the control group,and serum IgG, IgM, CD4+ and CD4+/CD8+
increased significantly.Conclusion:Glutaminecan significantly improve the intestinal mucosal barrier function, and promote the immune
function and nutritional status in treatment of sepsis patients, it can also reduce the translocation of intestinal bacteria and endotoxin. |
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