| 石春林 刘前芳 刘琳 周静雯 何云.脑脊液PCT、VEGF、S-100B、NSE、MMP 及CGRP水平在病毒性脑膜炎
患儿中的临床研究[J].,2015,15(13):2525-2527 |
| 脑脊液PCT、VEGF、S-100B、NSE、MMP 及CGRP水平在病毒性脑膜炎
患儿中的临床研究 |
| The Clinical Study on Levels of PCT, VEGF, S-100B, NSE, MMP and CGRPin Cerebrospinal Fluid of Children With Viral Meningitis |
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| DOI： |
| 中文关键词: 病毒性脑膜炎 脑脊液 降钙素原 血管内皮生长因子 S-100B 神经元特异性烯醇化酶 基质金属蛋白酶 降钙素基因相
关肽 |
| 英文关键词: Viral meningitis Cerebrospinal fluid PCT VEGF S-100B NSE MMP CGRP |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨脑脊液降钙素原（PCT）、血管内皮生长因子（VEGF）、S100B蛋白（S-100B）、神经元特异性烯醇化酶（NSE）、基质
金属蛋白酶（MMP）及降钙素基因相关肽（CGRP）水平联合检测在病毒性脑炎患儿中的诊断价值和意义。方法：选取2012 年6 月
至2014 年6 月收治的病毒性脑炎患儿106 例作为研究组，选取同时期来我院进行健康体检的60 例儿童作为对照组，比较两组
脑脊液PCT、VEGF、S-100B、NSE、MMP及CGRP水平，并分析研究组依照不同层次分组后以上各指标的差异。结果：研究组脑脊
液中PCT、VEGF、S-100B、NSE、MMP 及CGRP 水平明显高于对照组，差异具有统计学意义（P＜0.05）；研究组重症患儿高于轻症
患者，急性期患者高于非急性期患儿，差异均具有统计学意义（P＜0.05）。以上各指标中任意二种、三种、四种及五种联合检测，其
诊断效能均在0.923-0.967 之间，六种指标联合检测的效能最高为0.975。结论：病毒性脑膜炎患儿血清及脑脊液PCT、VEGF、
S-100B、NSE、MMP及CGRP水平均呈现升高的趋势，且不同严重程度及分期患儿的以上指标均有一定的差异，六种指标联合检
测诊断病毒性脑炎患儿的效能最高。 |
| 英文摘要: |
| Objective:To investigate the diagnosis value and significance of levels of cerebrospinal fluid PCT, VEGF, S-100B,
NSE, MMP and CGRP in children with viral meningitis.Methods:106 cases of children with viral meningitis who were diagnosed and
treated and in our hospital from June 2012 to June 2014 were selected as observation group,and 60 children were selected as control
group during the same period, then the cerebrospinal fluid PCT,VEGF, S-100B, NSE, MMP and CGRP levels of the two groups were
compared, and also compared among those with different severity and stages of meningitis.Results:The cerebrospinal fluid PCT, VEGF,
S-100B, NSE, MMP and CGRP levels of observation group were higher than those of the control group. Besides, among the observation
group, indexes were higher in acute stage children than in children of other stage (P<0.05); These indexes were higher in severe meningitis
children than in mild meningitis children, the differences were statistically significant (P<0.05). The diagnostic efficacy of joint detection
of any two, three, four or five kinds of the above indexes was between 0.923-0.967, joint detection efficiency of six kinds was up to
0.975.Conclusion:The cerebrospinal fluid PCT, VEGF, S-100B, NSE, MMP and CGRP levels of children with different severity of viral
meningitis shows an significant increasing trend, and there are differences of above indicators in different severity and staging. Combined
detection of the six indexes in diagnosis of viral encephalitis is of the highest efficacy. |
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