| 刘惟蜻 邬素萍 高静 周洪海 王晓红.精氨酸加压素与抑郁症的研究进展[J].,2015,15(11):2188-2190 |
| 精氨酸加压素与抑郁症的研究进展 |
| Advances in Arginine Vasopressin and Depression |
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| DOI： |
| 中文关键词: 抑郁症 AVP 加压素系统 AVP 受体拮抗剂 |
| 英文关键词: Depression AVP Vasopressin system AVP receptor antagonist |
| 基金项目:国家自然科学基金项目(30971045；C090302) |
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| 中文摘要: |
| 抑郁症是目前最为常见的情感性精神障碍，以情绪及应激的行为反应失调为主要特征。迄今为止，抑郁症的病因及发病机
制不明，但相关的神经生化假说很多。精氨酸加压素（Arginine vasopressin, AVP）作为一种神经肽，因其在抑郁症中改变明显而越
来越受关注。加压素系统包括丘脑大细胞性神经元、丘脑视上核和室旁核小细胞性神经元、视交叉上核（Suprachiasmatic nucleus,
SCN）及下丘脑外边缘脑区。AVP在大脑区域分布不同，对大脑功能的调节机制也不一样。本文从加压素系统及血浆AVP 在抑郁
症中的研究进展、AVP受体拮抗剂在抗抑郁治疗方面的研究现状进行综述。 |
| 英文摘要: |
| Depression is the most common affective disorder at present, characterized by imbalance of behavioral responses to
emotion and stress. The etiology and pathogenesis of depression haven’t been known , but there are numerous relevant neurochemical
hypotheses. As a neuropeptide, AVP accepts more and more attention because of its significant changes in depression. Vasopressin
system includes the large magnocellular neurons of hypothalamus, the small parvocellular neurons in supraoptic nucleus and
paraventricular nucleus, the suprachiasmatic nucleus, and the limbic area out of the hypothalamus. While AVP distributing in different
brain regions, its regulatory mechanisms on brain functions are distinctive. This paper reviewed the vasopressin system, advanced
research between central as well as plasma AVP and depression, the status of AVP receptor antagonist in antidepressant treatment etc. |
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