| 杨忠路 王辉山 刘涛 张仁腾 姜辉.心肌坏死标志物联合检测对急性心肌梗死早期诊断及鉴别的价值[J].,2015,15(11):2086-2088 |
| 心肌坏死标志物联合检测对急性心肌梗死早期诊断及鉴别的价值 |
| Significance of Combined Detection of Myocardial Necrosis Markers forEarly Diagnosis of Acute Myocardial Infarction |
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| DOI： |
| 中文关键词: 急性心肌梗死 心肌坏死标志物 联合检测 |
| 英文关键词: Acute myocardial infarction Myocardial necrosis markers Combined detection |
| 基金项目:辽宁省科学技术计划项目（2013225089） |
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| 中文摘要: |
| 目的：探讨心肌坏死标志物联合检测在急性心肌梗死早期诊断及鉴别中的意义。方法：选取2010 年12 月至2013 年5 月我
院收治的90 例患者，45 例确诊急性心肌梗死患者为观察组，其余45 例非急性心肌梗死患者为对照组。分别采集两组患者静脉血
4 mL用于检验。采用免疫抑制法测定患者血清中肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）含量，采用电化学发光法检测肌钙
蛋白I（cTnI）和肌红蛋白（MYO）含量。观察并比较不同时间点两组患者血清中CK、CK-MB、cTnⅠ及MYO 含量的变化情况。结
果：与对照组比较，观察组的血清CK、CK-MB、cTnⅠ及MYO 的含量明显升高，其中CK 及MYO 升高最为显著，差异具有统计
学意义（P<0.05）。CK、CK-MB 在发病3~6 h后快速升高，24 h达高峰；cTnⅠ前24 h与CK-MB 同步，但维持时间较长；MYO 在发
病后1~2 h发生异常，12 h达峰值（P＜0.05）。结论：心肌坏死标志物联合检测可提高急性心肌梗死的检出率，有助于疾病的及时
发现、诊断和治疗。 |
| 英文摘要: |
| Objective:To investigate the significance of detection of combined myocardial necrosis markers in the early diagnosis
and differentiation of acute myocardial infarction.Methods:90 patients who were treated in our hospital from December 2010 to May
2013 were enrolled. Among the 90 patients, 45 with the acute myocardial infarction were selected as the observation group, while
another 45 patients without acute myocardial infarction were named the control group. Immunosuppression was used to determine the
concentrations of creatine kinase (CK) and CK-MB, and electrochemiluminescence was used for the detection of troponin Ⅰ(cTnⅠ) and
myoglobin (MYO). The concentrations of CK, CK-MB, cTnⅠ and MYO at different time in the serum of patients were recorded and
compared between the two groups.Results:Compared with the control group, CK, CK-MB, cTnⅠ and MYO levels in the observation
group increased significantly, and the CK and MYO obviously increased (P<0.05); CK and CK-MB levels increased rapidly 3-6 h, and
peaked at 24 h; cTnⅠ level was synchronous with CK-MB in 24 hours and maintained longer in the blood; MYO level occurred
abnormality at 1 2 h after the onset and reached the peak in 12h, which was significantly earlier than the other three indicators (P <0.05).Conclusion:Combined myocardial necrosis markers can improve the detection rate of acute myocardial infarction and contribute to
timely detection, diagnosis and treatment of the disease. |
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