| 李丹 余爱云 余亚娟 谢珊艳 刘怡安.苦参碱联合顺铂对小鼠宫颈癌U14 移植瘤抑制作用的影响[J].,2015,15(11):2027-2030 |
| 苦参碱联合顺铂对小鼠宫颈癌U14 移植瘤抑制作用的影响 |
| Inhibitory Effect of Matrine Combined Cisplatin on Murine CervicalCancer of U14 Xenograft |
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| DOI： |
| 中文关键词: 苦参碱 顺铂 宫颈癌 U14 |
| 英文关键词: Matrine Cisplatin Cervical cancer U14 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨苦参碱联合顺铂对小鼠宫颈癌U14 移植瘤的抑制作用。方法：制备宫颈癌移植瘤小鼠模型，随机分为苦参碱高、
中、低剂量组，顺铂联合苦参碱高、中、低剂量组，顺铂组及对照组8 组，给予不同治疗后检测计算肿瘤抑瘤率，胸腺指数，脾脏指
数，肌酐及尿素氮水平。结果：①相比对照组，其余各组瘤重均有减少，其中顺铂组、苦参碱高剂量组及联合用药各组瘤重减少明
显，差异有统计学意义（P＜0.01）；②相比对照组，顺铂组胸腺指数及脾脏指数显著下降（P＜0.01），相比对照组及顺铂组，苦参碱
组与联合顺铂组胸腺指数及脾脏指数均增高，差异有显著性意义（P＜0.01）；③联合高剂量组肌酐、尿素氮值相比顺铂组显著降低
（P＜0.01），联合中剂量组相比顺铂组减少（P＜0.05），低剂量组下降不明显（P＞0.05）。结论：一定浓度的苦参碱对小鼠宫颈癌U14
移植瘤有抑制作用，同顺铂联合应用可增强顺铂的抗肿瘤效果，并减轻后者的毒副作用，对机体免疫力提升亦有促进。 |
| 英文摘要: |
| Objective:To explore the inhibitory effect of Matrine combined cisplatin on murine cervical cancer by U14 xenograft.Methods:Cervical cancer transplantation tumor model in mice was perpetrated, all mice were randomly divided into 8 groups: matrine
groups( high, mediumand low dose group), cisplatin plus bitter and alkali groups(high, medium and low dose group), cisplatin group and
control group. After treatment, tumor inhibition rate,thymus index, spleen index, creatinine and urea nitrogen levels were calculated.Results:(1) Compared with the control group, tumor weight of other groups were reduced, in the cisplatin group, the matrine high-dose
group and combination group, tumor weight decreased obviously, the difference was statistically significant(P<0.01). (2)Compared with
control group, the thymus index and spleen index of cisplatin group decreased significantly (P<0.01), compared with the control group
and cisplatin group, thymus index and spleen index of matrine and combined cisplatin group increased significantly, with significant
differences(P<0.01). (3) Compared with cisplatin group, creatinine and urea nitrogen values of high dose combination group decreased
significantly (P<0.01), values for medium dose combination group also decreased (P<0.05), but no significant decrease was observed in
low dose group (P>0.05).Conclusion:A certain concentration of bitter and alkali has inhibitory effect on murine cervical cancer of U14
xenograft. When combined in treatment, it can enhance the anti-tumor effect of cisplatin, and reduce the side effects of the cisplatin, the
immunity can be also promoted as well. |
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