| 彭奔 李靳 刘苗苗 张长城.精原干细胞与睾丸生殖衰老的研究进展[J].,2015,15(10):1977-1978 |
| 精原干细胞与睾丸生殖衰老的研究进展 |
| Ageing of the Spermatogonial StemCells and Testicular Germ |
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| DOI： |
| 中文关键词: 精原干细胞 niche 生殖衰老 |
| 英文关键词: Spermatogonial stemcells Niche Reproductive senescence |
| 基金项目:国家自然科学基金项目（81173375） |
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| 中文摘要: |
| 雄性睾丸内精子的生成及其质量随年龄增长逐渐降低。精原干细胞是精子生成的起点，其数量和质量决定了精子的生成，
而精原干细胞niche 是调节精原干细胞自我更新与分化的重要因素。在衰老过程中，干细胞微环境退化，精原干细胞自我更新和
分化失衡，被认为是衰老导致睾丸生殖功能衰退的的主要因素。本文将综述衰老引起的精原干细胞与niche 变化及其对生殖的影
响相关研究进展。 |
| 英文摘要: |
| Both quantity and quality of male testicular sperm decrease with age. Spermatogonial stem cells are the starting point
for sperm production, which determines the quantity and quality of sperm production, and spermatogonial stem cells niche is to regulate
spermatogonial stem cell self-renewal and differentiation of important factors. In the aging process, stem cell micro-environmental
degradation, spermatogonial stem cell self-renewal and differentiation imbalance is considered to be aging causes testicular germ
functional decline of the main factors. This article provides an overview of aging caused by spermatogonial stem cells and niche change
and its effects on reproduction-related research. |
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