| 刘祥超 周恒 詹晓平 刘增路 毛振民.NK1 受体拮抗剂的应用研究进展[J].,2015,15(10):1938-1942 |
| NK1 受体拮抗剂的应用研究进展 |
| The Application of NK1 Receptor Antagonists: Research Advances |
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| DOI： |
| 中文关键词: P物质 NK1 受体 NK1 受体拮抗剂 应用 |
| 英文关键词: Substance P NK1 receptor NK1 receptor antagonist Application |
| 基金项目:国家科技重大新药创制专项（2010ZX09401-404） |
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| 中文摘要: |
| 神经激肽中P物质是中枢神经系统最重要的神经递质之一，通过与其最主要的受体NK1 受体结合在多种疾病的病理过程
中发挥作用。NK1 受体拮抗剂近年来在临床上应用广泛，不仅能治疗化疗引起的恶心，呕吐，而且在缓解抑郁，抗肿瘤，治疗急性
尿失禁方面都显示有很好的疗效。本文就近年来NK1 受体拮抗剂的应用研究进展进行综述。 |
| 英文摘要: |
| Substance P is one of the most important neurotransmitter in the nervous system. It plays an important role in the
pathological process of many diseases through combining with its main receptor: NK1 receptor. The antagonists of NK1 receptor that are
widely used in recent clinical treatments can not only be used in the treatment of CINV, but also have excellent effects on antitumor ,
antidepressant and treating UUI. In this review, the relevant study results in this field are described. |
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