| 李启荣 何红波 黄雄 张春平 王志杰 王达平 江妙玲 蓝晓嫦 段炼 张敏玲.氯胺酮麻醉的MECT对难治性抑郁症患者认知功能的影响[J].,2015,15(9):1715-1717 |
| 氯胺酮麻醉的MECT对难治性抑郁症患者认知功能的影响 |
| The Cognitive Effects of Ketamine as Anesthesia on MECT in Patientswith Refractory Depressive Disorder |
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| DOI： |
| 中文关键词: 改良性电抽搐治疗 难治性抑郁症 氯胺酮 认知功能 |
| 英文关键词: MECT TRD Ketamine Cognitive function |
| 基金项目:国家自然科学基金面上项目（81371506）；广东省自然科学基金博士启动项目（S2013040012414）；
广东省科技计划项目（2013B021800043） |
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| 中文摘要: |
| 目的：探讨氯胺酮麻醉下的MECT治疗难治性抑郁症的安全性和治疗前后的认知功能变化。方法：入组60 例需要MECT
治疗的难治性抑郁症患者，随机分为氯胺酮组（30 例）使用氯胺酮诱导麻醉的MECT 治疗；异丙酚组（30 例）使用异丙酚诱导麻醉
的MECT治疗。入组患者在基线期及MECT 治疗8 次后完成汉密尔顿抑郁量表（HAMD）评定及连线测验A&B、威斯康星卡片分
类测验、汉诺塔测试，出组时评定副反应量表。结果：两组患者治疗结束后认知功能均较治疗前明显降低，异丙酚组较氯胺酮组降
低更明显。结论：氯胺酮MECT 治疗难治性抑郁症安全有效，对患者的认知功能损害较异丙酚组轻，未出现严重副作用。 |
| 英文摘要: |
| Objective:To investigate the cognitive function defect of patients with TRD after ketamine-MECT.Methods:60 TRD
inpatients were randomly divided into two groups: propofol-MECT group, and ketamine-MECT group. Both patients were asessed
HAMD, Trail Making Test A&B, WCST, Tower of Hanoi before and after the eighth time of MECT, and TESS was examined at the end
of MECT treatment.Results:HAMD score of the two groups were lower after MECT treatment respectively and reach the clinical
recovery criterion. The cognitive function of patients in two groups were deteriorated remarkable, while which in propofol-MECT group
were worse than that in ketamine-MECT group.Conclusion:Ketamine-MECT in treatment of TRD is safe and effectively, which cause
the cognitive function damage of TRD patients is mildlier than propofol-MECT, and no serious side effect was observed. |
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