| Objective:To investigate the effects of Shenkang Injection (SKI) on diabetic nephropathy (DN).Methods:DN rat
models were established by STZ 65 mg/kg, intraperitoneal injection, and then divided into five groups; SKIH, SKIMand SKIL were give
SKI 10 mL/kg, 5 mL/kg, 2.5 mL/kg, 2 times/d, respectively; While control group and model group were given saline 5 ml/kg, 2 times/d.
After 8 weeks administration, the related biochemical indices were detected.Results:SKI could significantly decrease the level of Scr and
BUN; And it notably decreased the concentrations of T-CHO, TG, LDL and increased the level of HDL in serum; It can increase the
activity of CAT and T-SOD, decrease the concentrations of NO and MDA and inhibit the activity of NOS.Conclusion:SKI can relieve
the damage by high glucose in renal and has obvious therapeutic effect on DN. |
