王 飞 王 丹 申宝忠.冠状动脉易损斑块影像学最新研究进展[J].,2015,15(7):1386-1389 |
冠状动脉易损斑块影像学最新研究进展 |
The Evolution of Coronary Artery Vulnerable Plaque in ClinicalImaging Methods |
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DOI: |
中文关键词: 冠状动脉 易损斑块 MSCT MRI IVUS OCT |
英文关键词: Coronary artery Vulnerable plaque MSCT MRI IVUS OCT |
基金项目:国家自 然科学基金重点项目(81 130028);国家自然科学基金重大国际(地区)合作项目( 31210103913);
黑龙江省科技攻关重大项目(GA1 2C302); |
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中文摘要: |
冠心病( CAD)是世界上致死率最高的疾病之一, 其中, 以急性冠状动脉综合征( ACS)病情最为 凶险, 而近 70%的急性冠脉
事件并不是由显著地冠状动脉狭窄引 起, 而是由 冠状动脉易损斑块( vulnerable plaque)破裂造成的急性狭窄, 以及其后血栓形成
所致,因 此冠状动脉易损斑块是导致急性冠状动脉综合征的主要元凶,因 此需要早期发现易损斑块并积极进行干预。 近两年来,
CT、 MRI、血管内 超声( IVUS)和光学相干断层成像( OCT)广泛应用 于易损斑块的评估并取得显著进展, 而分子影像学能从分子层
面揭示易损斑块形成机制以及更加早期识别 斑块进行。 本文简 要总结近两年影像学方法对易损斑块的最新研究进展及热点。 |
英文摘要: |
Coronary artery disease is one of the most fatal diseases all over the world, of which, acute coronary syndrome (ACS)
is the most pernicious. 70% of acute cardiac events are not caused by serious stenosis, but by acute stenosis followed by rupture of vulnerable plaque and thrombus afertwards. The vulnerable plaque of coronary artery plays the major role in the onset of acute coronary syndrome, so, it should be early diagnosed and intervened positively. With the technological progress, CT, MRI, intravascular unltrasound
(IVUS) and optical coherence tomography (OCT) have been successfully used to evaluate the vulnerable plaque. Molecular imaging can
reveal molecular mechanism of the coronary plaque and discover the plaque at even earlier stage. So, it is of great importance to make
clear the advantages and disadvantages of all the methods and the research hotspots in the medical imaging field. |
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