| 张巍巍 1 刘 云顺 2 王 颖 1 王 青.S- 腺苷蛋氨酸在肝病患者中抗抑郁作用的研究进展[J].,2015,15(6):1196-1197 |
| S- 腺苷蛋氨酸在肝病患者中抗抑郁作用的研究进展 |
| Research on Antidepressant Effects of S-adenosylmethionine in Patients withLiver Diseases |
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| DOI： |
| 中文关键词: 胆汁淤积 焦虑 抑郁 S- 腺苷蛋氨酸 |
| 英文关键词: Cholestasis Anxiety Depression S-adenosylmethionine |
| 基金项目:青岛市科技发展计划项目（ 11 -2-3-2-c81-nsh） |
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| 中文摘要: |
| S- 腺苷蛋氨酸( S-adenosyl-L-methionine, SAMe) 是一种天然分子存在于人体所有细胞中，在肝脏、肾上腺以及松果体中具有
较高浓度，在大脑中亦均匀 分布。 S- 腺苷蛋氨酸通过抗氧化自 由基及促进肝细胞再生等机制 对肝细胞具有多 重保护作用 长久以
来被广泛应用 于肝病所致的肝内 胆汁淤积、抗肝纤维化等治疗 。 近年来, 研究亦发现 S- 腺苷蛋氨酸可增加患者脑中神经元膜的
流动性及促进兴奋性神经递质的产生等对改善肝病患者情绪、治疗肝病患者抑郁症等方面具有重要的双重作用。 通过静脉或口
服用 药， 均可提高患者脑脊液中 SAMe 浓度，对于轻、中度抑郁患者的辅助治疗， 更具安全性、有效性， 这为 人类的 " 生理 - 心理 "
疾病的治疗带来更广阔的应用 前景。 现将其对肝病患者抗抑郁的作用 机制及临床应用 综述如下。 |
| 英文摘要: |
| S-adenosylmethionine (S-adenosyl-L-methionine, SAMe) is a natural molecule exsisting in all human cells,
expressing a higher concentration in the liver, adrenal gland as well as in the pineal gland, and also uniformly distributed in the brain.
S-adenosylmethionine has long been widely used in most of intrahepatic cholestasis and liver fibrosis diseases because of its mutiple
protection mechanisms of liver cells by anti-oxidant free radicals and promoting the regeneration of liver cells. Moreover, in recent years,
literature illustrates that it has a vital dual role in improving the mood and treating depression of patients with liver diseases by increasing
the neurons membrane fluidity in patients' brains and promoting the generation of excitatory neurotransmitter. The cerebrospinal
concentration of SAMe can be improved by either intravenous or oral intake. SAMe safely and efficiently serves as an adjuvant
medication for patients with mild to moderate depression, which will bring broad application prospects for the treatment of human
physiological - psychological diseases. Therefore, its antidepressant mechanisms and clinical applications in patients with liver diseases
are summarized below |
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