| 王乐 毕胜 范晓雪 王春燕 吕政.维生素D 及其受体在帕金森病中的作用[J].,2015,15(3):594-597 |
| 维生素D 及其受体在帕金森病中的作用 |
| Effects of Vitamin D and its Receptors on Parkinson's Disease |
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| DOI： |
| 中文关键词: 帕金森病 维生素D 维生素D受体 维生素D 受体基因多态性 免疫调节 |
| 英文关键词: Parkinson's disease Vitamin D Vitamin D receptor Vitamin D receptor gene polymorphism Immune regulation |
| 基金项目:教育部留学回国人员科研启动基金项目（教外司留【2004】527 号）；
哈尔滨市科技创新人才研究专项基金项目（2011 RFQYS092） |
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| 中文摘要: |
| ：帕金森病（Parkinson's disease, PD）是一种常见的中枢神经系统退行性疾病，引起帕金森病的发病机制至今尚未明确。帕金
森病患者及老年人普遍存在维生素D 缺乏，这可能是帕金森病的重要发病机制之一。由于维生素D 具有免疫调节，抗氧化，调节
神经营养因子，降低神经毒性的功能，能同时针对几种导致神经退行性病变因素发挥作用，特别是老年人纠正维生素D 缺乏可能
会阻止神经元的损失和PD 相关的认知功能下降。因此补充维生素D 可能成为治疗PD 的方法。近年来研究发现，维生素D 受
体基因多态性与帕金森病的发病有相关性。该文就维生素D 及其受体在帕金森病中可能发生的保护作用及其机制作一综述。 |
| 英文摘要: |
| Parkinson's is a common neurodegenerative disease in the central nervous system and the pathogenesis of it has not
been confirmed yet. It is a common phenomenon that most of the elderly and the people with Parkinson's disease are deficient in vitamin
D which may be an important pathogenic factor for Parkinson's disease. Vitamin D has multiple functions that include the immune
regulation, anti-oxidation regulation of neurotrophic factors, reducing neurovirulence which would help people avoid
hyperparathyroidism. To supplement vitamin D may prevent the loss of neurons and slow down the PD-related cognitive from decline for
the elderly. Therefore, vitamin D plays a role in the therapies for PD. Recently, more and more researches have proved that vitamin D and
its receptors might be relative to the Parkinson's disease. This article reviews the potential effect of vitamin D and vitamin D receptor on
Parkinson's disease. |
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