| 郭敏 王玉晶 邱文丽 李姗姗.痛风患者血管内皮功能及颈动脉粥样硬化的临床研究[J].,2015,15(3):499-502 |
| 痛风患者血管内皮功能及颈动脉粥样硬化的临床研究 |
| Clinical Study of Endothelial Dysfunction and Carotid Atherosclerosis inPatients with Gout |
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| DOI： |
| 中文关键词: 痛风 尿酸 血管内皮功能 颈动脉内膜中层厚度 |
| 英文关键词: Gout Hyperuricemia Endothelial function Carotid artery intima-media thickness |
| 基金项目:黑龙江省教育厅科学技术研究课题（12541520） |
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| 中文摘要: |
| 目的：观察痛风患者氧化应激指标与颈动脉内膜中层厚度(IMT)的变化，探讨高尿酸引起内皮功能损伤和颈动脉粥样硬化的
机制。方法：选择痛风患者123 例，正常健康者116 例，检测两组患者血尿酸、细胞间粘附分子1（ICAM-1）、内皮素-1（ET-1）、一氧
化氮(NO)、纤溶酶原激活抑制剂-1(PAI-1)、收缩压、舒张压、空腹血糖、HDL-C、LDL-C、TC、TG等糖、脂代谢指标及颈动脉内膜中
层厚度（IMT）。分析痛风患者内皮损伤相关因子水平和颈动脉IMT 的关系。结果：痛风组血清细胞间粘附分子1（ICAM-1）、内皮
素-1（ET-1）、纤溶酶原激活抑制剂-1(PAI-1) 水平较对照组增高，颈动脉IMT 明显增厚，NO水平较对照组降低，差异均有统计学
意义(P<0.05)。血尿酸水平、ICAM-1、ET-1、PAI-1与IMT 密切相关(P<0.01)。结论：痛风患者较对照组存在更明显的代谢紊乱，血管
内皮功能损伤，更易发生动脉粥样硬化。 |
| 英文摘要: |
| Objective:To investigate the indicators of oxidative stress in patients with gout and carotid artery intima-media
thickness (IMT) changes and to explore the mechanism underlying high uric acid-caused endothelial dysfunction and carotid
atherosclerosis.Methods:123 gout patients and 116 normal controls were enrolled in the study. Intercellular adhesion molecule-1
(ICAM-1), endothelin-1 (ET-1), nitric oxide (NO), fibrinolysis plasminogen activator inhibitor-1 (PAI-1), systolic blood pressure,
diastolic blood pressure, fasting glucose, HDL-C, LDL-C, TC, TG and carotid artery intima-media thickness (IMT) were measured in the
two groups. And the relationship between endothelial dysfunction and carotid IMT was analyzed in patients with gout.Results:The
serum intercellular adhesion molecule-1 (ICAM-1), endothelin-1 (ET-1), and plasminogen activator inhibitor-1 (PAI-1) levels were
significantly higher (P<0.01), the carotid IMT increased (P<0.01), and the NO level decreased (P<0.01) in gout patients compared with
those in the control group. Blood uric acid level, ICAM-1, ET-1 and PAI-1 were closely related to IMT.Conclusion:There are more
severe metabolic disorders and vascular endothelial dysfunction in gout patients than in the control group. Gout patients may be more
susceptible to atherosclerosis. |
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