| 朱晓南 宗利丽 付文博 郝双 管雁丞 张宸铭.miR-200 家族作为卵巢癌预后标志物的meta分析[J].,2015,15(2):343-346 |
| miR-200 家族作为卵巢癌预后标志物的meta分析 |
| Prognostic Role of miR-200 Family in Ovarian Cancer: a Meta-analysis |
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| DOI： |
| 中文关键词: miR-200 家族 卵巢癌 预后 肿瘤标记 Meta 分析 |
| 英文关键词: miR-200 family Ovarian cancer Prognosis Tumor markers Meta analysis |
| 基金项目:广东省人口和计划生育委员会科研项目（20110272） |
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| 中文摘要: |
| 目的：系统评价miR-200家族（miR-200a、miR-200b、miR-200c、miR-141、miR-429）的表达与卵巢癌预后之间的关系。方法：
仔细检索搜索美国国立图书馆（PubMed），荷兰医学文摘（EMBASE）以及ISI Web of Science、CNKI、万方等数据库，与miR-200 家
族相关的卵巢癌预后的文献。检索日期为数据库的建库时间至2013 年9 月20 日。提取与miR-200 家族相关卵巢癌预后的相应
数据，应用Stata11.0 软件进行Meta 分析。结果：共有7 篇研究符合入选标准,累积肿瘤组织577 例。Meta 分析显示, miR-200 家
族低表达组的合并优势比是高表达组的1.347 倍(95%CI: 1.052,1.725)。miR-200a、miR-200c、miR-141 的亚组分析结果分别为
1.091（95%CI：0.718，1.659）、1.285（95%CI：0.765，2.161）, 1.122 (95%CI: 1.043-1.208)。miR-200 家族、miR-141 与卵巢癌的预后之
间的关系有统计学意义(P = 0.018, P = 0.002)。结论：miR-200家族在卵巢癌的预后判断中可能起到预后标记物的作用。 |
| 英文摘要: |
| Objective:To systemically evaluate the relationship between miR-200 family and the prognosis of ovarian cancer.Methods:A computer-based retrieval of PubMed, EMBASE, Web of Science, CNKI and Wanfang Database was performed for
correlative literature to aggregate the survival results from their establishment to September 2013. Relevant data were extracted from
studies investigating the relationship between miR-200 family expression and survival in ovarian cancer patients. The data were analyzed
with meta analysis using Stata v11.0 software.Results:Seven studies were identified, involving 577 cases with ovarian cancer.
Meta-analysis results showed that, the combined hazard ratio (HR) for miR-200 family in ovarian cancer was 1.347 (95%CI: 1.052,
1.725). Subgroup of miR-200a, miR-200c and miR-141 subjects for survival were 1.091（95%CI：0.718, 1.659）, 1.285（95%CI：0.765,
2.161）, and 1.122 (95% CI: 1.043, 1.208), respectively. The risk of miR-200 family, miR-141 for prognosis in ovarian cancer patients
was significant (P = 0.018, P = 0.002)).Conclusion:miR-200 family may act as a prognostic biomarker. |
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