| 周璇 阳学风.神经酰胺诱导肿瘤细胞凋亡的机制研究进展[J].,2015,15(1):174-177 |
| 神经酰胺诱导肿瘤细胞凋亡的机制研究进展 |
| Progression of Mechanismthat Ceramide-induced Apoptosis of Tumor Cells |
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| DOI： |
| 中文关键词: 神经酰胺 细胞凋亡 Jun氨基末端激酶 P38 |
| 英文关键词: Ceramide Apoptosis JNK P38 |
| 基金项目:国家自然科学基金项目（81373465） |
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| 中文摘要: |
| 神经酰胺（ceramide，Cer)作为一种神经鞘磷脂分子,不仅是细胞膜的组成成分，而且可以作为各种信号转导途径的第二信
使，参与细胞增殖、分化、衰老和凋亡等生命活动的调节。Cer的合成、代谢及信号转导在肿瘤发生发展甚至耐药和抵抗放射治疗中有着密切的关系。Cer 可以被诸如肿瘤坏死因子alpha(Tumor necrosis factor-alpha, TNF-alpha)、激素、电离辐射和化疗药物等细胞外信号和受体激活，其主要可以通过内源性凋亡途径和外源性凋亡途径诱导肿瘤细胞凋亡的发生。在肿瘤细胞凋亡发生过程中，Cer 通过激活Jun 氨基末端激酶（JNKs)、有丝分裂原活化蛋白激酶/ 细胞外信号调节蛋白激酶（MAPK/ERK）和P38 等信号通路以及蛋白激酶、组织蛋白酶D、蛋白磷酸酶1（Protein phosphatase1，PP1）和蛋白磷酸酶2A(Protein phosphatase2A，PP2A)等效应分子介导肿瘤细胞凋亡。本文综述近年来有关Cer在应激反应级联以及肿瘤细胞凋亡中的作用的研究进展。 |
| 英文摘要: |
| As a kind of sphingomyelin molecule, Ceramide is not only the component of cell membrane, but also can be used as
the second messenger of various signal transduction pathways involved in the regulation of cell proliferation, differentiation, senescence
and apoptosis. Synthesis,metabolismand signal transduction ofCer have a close relationshipwith the occurrence and development of tumor,
even with drug resistance and resistance to radiation therapy. Cer can be activated by extracellular signals and receptors such as tumor
necrosis factor alpha (Tumor necrosis factor 琢, TNF-琢), hormone, ionizing radiation and chemotherapy drugs, the apop- tosis of tumor
cells can be induced mainly by the intrinsic apoptosis pathway and the extrinsic apoptosis pathway. In the process of apoptosis of tumor
cells, Cer mediates the apoptosis of tumor cells by activating c-Jun NH2-terminal kinase (JNK), mitogen-activated protein kinase or extracellular
signal-regulated protein kinase (MAPK or ERK), P38 and other signal pathways, meanwhile through effector molecules such
as protein kinases, cathepsin D, protein phosphatase 1 (Protein phosphatase1, PP1) and protein phosphatase 2A (Protein phosphatase2A,
PP2A), etc. This paper reviews the research progress on the role of Cer in stress response cascade and apoptosis of tumor cells in recent
years. |
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