| 张思雅 周艳艳 谢瑞强 曲晓莉 史宇晨 吕亚娜 贾婿 冯陈晨 李琬 何月涵 黄昊 侯敏 陈丽娜.基于人类信号网络和表达谱数据研究静脉血栓复发机制[J].,2015,15(1):131-138 |
| 基于人类信号网络和表达谱数据研究静脉血栓复发机制 |
| Researching Recurrence Mechanismof Venous ThromboembolismBased on Human Singaling Network and GeneExpression Profile Data |
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| DOI： |
| 中文关键词: 静脉血栓 华法令 基因表达谱 人类信号网络 模块 |
| 英文关键词: Venous thromboembolism Warfarin Gene expression profile Human signaling network Module |
| 基金项目:黑龙江省教育厅基金项目（12511271）；国家自然科学基金项目（61272388）；黑龙江省自然科学基金项目（F201237）；
黑龙江省研究生创新科研资金项目（YJSCX2012-209HLJ）；黑龙江省大学生创新创业训练基金项目（2012-011HYD）；
哈尔滨医科大学本科生创新创业基金项目（2012-071HBUYD） |
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| 中文摘要: |
| 目的：静脉血栓是一种高复发风险和高致死率的疾病，其形成和复发的分子机制尚不明确。基于人类信号网络和基因表达
谱数据可针对静脉血栓经华法令抗凝治疗后的复发机制进行研究。方法：结合表达谱数据和人类信号网络，设计差异模块筛选策
略，通过功能分析、差异表达分析和已知血栓相关基因及药物靶基因的互作关联研究，获得与静脉血栓复发相关的显著差异模
块。结果：最终获得8 个与静脉血栓复发密切相关的显著差异模块，评估了华法令治疗静脉血栓的效能，提出了联合用药的3种
可能途径。结论：应用本文提出的整合筛选策略，能识别与静脉血栓复发相关的模块，探究静脉血栓复发的分子机制和评估华法
令的治疗效能。还提供了潜在的联合用药途径，这对治愈血栓、防治血栓复发及复发机制的研究具有重要意义。 |
| 英文摘要: |
| Objective:Venous thromboembolism is a disease having high risk recurrence and mortality, and the molecular
mechanism of formation and recurrence is not clear. Recurrence mechanism of venous thromboembolism after anticoagulation therapy
with warfarin could be investigated based on human singaling network and gene expression profile date.Methods:We integrated gene
expression profile data and human singaling network in order to design a screening significant differential module strategy. We obtained
significant differential modules related to recurrence venous thromboembolism via functional analysis, differential expression analysis
and interaction analysis of known genes and drug target genes associated with thromboembolism.Results:Finally eight significant
differential modules closely related to recurrence venous thromboembolism were obtained, and then were used to assess the efficacy of
warfarin. Three possible ways of drug combination were also presented.Conclusion:Our integrated screening strategy not only identified
modules closely related to recurrence venous thromboembolism, but also investigated recurrence mechanismof venous thromboembolism
and assessed the efficacy of warfarin. Our research provided potential route of administration of drug combination. It would be greatly
significant for curing venous thromboembolism, the prevention and treatment of recurrence venous thromboembolism and recurrence
mechanismstudy. |
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