| 李珊珊1 袁婧1 吴剑平1 黄立师1 朱永俸1 刘佳2△.黄芪多糖抗小鼠疲劳的作用机制研究[J].,2014,14(36):7052-7055 |
| 黄芪多糖抗小鼠疲劳的作用机制研究 |
| Study on the Mechanismof Antifatigue Effect on Mice of AstragalusPolysaccharides |
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| DOI： |
| 中文关键词: 黄芪多糖 游泳力竭 抗氧化 抗疲劳 能量支持 |
| 英文关键词: Astragalus polysaccharides Swimming exhaustion Antioxidant Fatigue resistance Energy support |
| 基金项目:2012 年度湖南省大学生研究性学习和创新性实验计划项目（444 号）；湖南省教育厅科学研究项目(13C1131) |
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| 中文摘要: |
| 目的：探讨黄芪多糖对小鼠的抗疲劳作用及机制。方法：该研究分为实验组和对照组两组，实验组设置三组剂量
0.2，0.05，0.0125 g/kg 对小鼠连续灌胃28 天，对照组给予蒸馏水灌胃，进行负重游泳试验计算游泳力竭时间，并检测小鼠全血中
血糖，血中乳酸含量，肝脏超氧化物歧化酶（SOD）、丙二醛（MDA）、乳酸脱氢酶（LDH）含量及肌组织中糖原储备量。结果：1).与对
照组相比较，黄芪多糖低剂量、高剂量组小鼠负重游泳时力竭时间明显延长；2).中剂量组小鼠运动后肝脏SOD 活力值比对照组
明显增高,高剂量组肌糖原的储存量明显升高，而低剂量组乳酸明显降低。结论：黄芪多糖具有抗疲劳作用，可能通过增加抗氧化
酶类SOD 活性、减少乳酸的产生及增加肌糖原能量储存等途径起作用。 |
| 英文摘要: |
| Objective:To study the anti-fatigue effect of astragalus polysaccharides on mice and the mechanism.Methods:This
research was divided into two groups, experimental group and control group. In the experimental group, mice were treated with
0.2，0.05，0.0125 g/kg astragalus polysaccharides respectively by lavage in 28 days, and in the control group, distilled water was used
instead.And then weight loading swimming experiment was carried out to calculate swimming exhaustion time, and the content of
glucose and LD in the blood，the vitality of SOD, MDA and LDH content in liver tissue，and muscle glycogen storage were also detected.Results:Compared with control group, swimming exhaustion time of low dose, high dose group were significantly prolonged. Liver SOD
vitality of middle dose group was improved notably. Muscle glycogen storage of high dose group was increased significantly compared
with the control group while the Lactic acid of low dose group was reduced obviously.Conclusion:Astragalus polysaccharide had the
anti-fatigue function, the mechanism of which is probably related to the increased activity of antioxidant enzymes SOD, reduced storage
of LD and enhanced content of muscle glycogen. |
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