| Objective:To investigate the renal protective effect of extracts from Rosa LaevigataMickx (RLM) on diabetic
nephropathy rats.Methods:After fed with a high-fat/high-sucrose/high-cholesterol diet, SD rats were administered STZ in a single dose
of 65mg/kg intraperitoneally (i.p.) to establish the diabetic nephropathy model, and then the diabetic nephropathy rats were randomly
selected and divided into two groups as follows: Diabetic nephropathy model group (DN), Diabetic nephropathy + Rosa LaevigataMickx.
group (DN + RLM, fed with extracts of RLM, 5 g/kg/d). And normal SD rats were into divided two groups as follows: normal control
group (NC), and normal control + Rosa LaevigataMichx. group (NC + RLM, fed with extracts of RLM, 5 g/kg/d). The fasting
blood-glucose(FBG), glycosylated haemoglobin(GHb), urine microalbumin and urinevolume in 24 h, blood urea nitrogen(BUN), serum
creatinine(Scr), total cholesterol(TC), triglyceride(TG) and the renal pathology change were measured in every group.Results:Compared
with the DN group, diabetic nephropathy rats which were treated with extracts of RLM, the disorder of FBG, GHb, urine microalbumin
and urine volume in 24h, dyslipidemia, renal dysfunction and the renal pathologicalchange were significantly ameliorated, and there was
no noticeable side effects of RLMon the rats.Conclusion:RLMis able to ameliorate the disorder of plasma blood glucose, dyslipidemia,
renal dysfunction and renal pathologicalchange, and has obvious renal protective effect on diabetic nephropathy rats. |
