| 王娟1 崔春黎2△ 富力3△ 鲁歧3 燕秋4 谢南姿1.人参皂甙Rg3对糖尿病肾病大鼠生化指标及病理的影响[J].,2014,14(36):7015-7018 |
| 人参皂甙Rg3对糖尿病肾病大鼠生化指标及病理的影响 |
| The Effect of Ginsenoside Rg3 on the Biochemical Indicators andPathological of Diabetic Nephropathy Rats |
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| DOI： |
| 中文关键词: 人参皂苷Rg3 糖尿病肾病 肾脏病理 |
| 英文关键词: Ginsenoside Rg3 Diabetic nephropathy Renal pathology |
| 基金项目:辽宁省企业博士后项目(106561) |
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| 中文摘要: |
| 目的：探讨人参皂苷Rg3 对糖尿病肾病大鼠生化指标及病理改变的影响。方法：30 只SD雄性大鼠按随机数字表法分为正
常对照组、模型对照组和人参皂甙Rg3 组。采用链脲佐菌素建立糖尿病肾病大鼠模型。造模成功后，Rg3 治疗组每天以Rg3（0.5
mg/kg）灌胃，余予以等量蒸馏水灌胃。30 天后分别测3 组大鼠血糖、24 小时尿蛋白、血肌酐，并予以HE 染色行肾组织活检。结果：
与正常组比较，模型对照组大鼠血糖、24 小时尿蛋白、血肌酐明显升高，肾小球体积增大，基底膜增厚、细膜基质增多，肾小球内炎
细胞浸润(P<0.01)。与模型对照组比较，人参皂甙Rg3组血糖、24 小时尿蛋白、血肌酐明显降低，肾小球基底膜增厚程度减轻，细胞
外基质堆积减少，差异具有显著性（P＜ 0.05）。结论：人参皂甙Rg3 能显著降低糖尿病大鼠血糖、血肌酐、24 h尿蛋白，能改善其肾
脏的病理损害。 |
| 英文摘要: |
| Objective:To investigate the effect of the ginsenoside Rg3 on the biochemical indicators and pathological of diabetic
nephropathy rats.Methods:Thirty Sprague-Dawley male rats were randomly divided into 3 groups: normal control group, model control
group and Rg3 treated group. The diabetic nephropathy rat model was induced by injection of streptozotocin (STZ, 65 mg/kg) in
abdominal cavity. After establishing the model, the Rg3 treated group was daily administrated with Rg3 (0.5 mg/kg) for 30 days, while
the other two groups were given distilled water. The blood glucose, twenty-four hours urine protein and serum creatine were measured
the day before the rats were killed when the 30 days of treatments had been completed. The renal pathological changes were evaluated by
HE staining.Results:The blood glucose, twenty-four hours urine protein and serum creatine increased significantly in the rats of model
control group. The volume of renal glomerulus enlarged. The basement membrane was thickened. The cell matrix was increased, as well
as some inflammatory cells were accumulated in renal glomerulus (P<0.01). Compared with that in the model control group, the level of
blood glucose, twenty-four hours urine protein and serum creatine were deduced obviously in Rg3 treated group. The extent of the
thickened basement membrane and the accumulation of extracellular matix reduced (P<0.05).Conclusion:The Rg3 can reduce the level
of the blood glucose, twenty-four hours urine protein, serumcreatine and the pathological damage of renal with diabetic nephropathy. |
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