| 熊延路 王明星 卢强 李小飞 朱爱林 赵晋波 韩勇.AMPK在非小细胞肺癌发生发展中的研究进展[J].,2014,14(34):6769-6772 |
| AMPK在非小细胞肺癌发生发展中的研究进展 |
| The Role of AMP Activated Protein Kinase in the Development ofNon-small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 腺苷酸活化蛋白激酶（AMPK） 非小细胞肺癌（NSCLC） 能量代谢 信号通路 |
| 英文关键词: AMP activated protein kinase (AMPK) Non-small cancer (NSCLC) Energy metabolism Signal pathways |
| 基金项目:国家自然科学基金项目（81001041） |
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| 中文摘要: |
| 腺苷酸活化的蛋白激酶（AMP activated protein kinase, AMPK），是细胞内重要的能量感受器，在调控细胞和机体的能量代谢中起到极其重要的作用。活化的AMPK 可以增强分解代谢，抑制合成代谢，应对细胞内外环境的刺激。并且影响细胞的生长、增殖、凋亡、自噬等基本生物学过程。肿瘤细胞具有独特的能量代谢方式———Warburg 现象，用于应对营养和能量的相对缺乏。AMPK 干扰肿瘤细胞的独特能量代谢方式，广泛影响肿瘤的发生、生长、转移，发挥重要的肿瘤拮抗作用。非小细胞肺癌（non-small cell cancer, NSCLC）是常见恶性肿瘤的一种，具有一般恶性肿瘤的特征，近年来在NSCLC的研究进程表明: AMPK 及其相关信号分子LKB1，PI3K/AKT，CaMKK-beta，PTEN 等与NSCLC 密切相关，活化相应通路或抑制相应通路，可显著拮抗NSCLC。从而AMPK 及其相关信号分子有可能作为抗NSCLC药物的作用靶点。 |
| 英文摘要: |
| AMP activated protein kinase (AMPK) is an important cellular energy sensor, which takes an exceedingly essential
part in the regulation of energy metabolism of the cell and the whole body. Once activated, AMPK can enhance catabolism and inhibit
anabolism to adapt to inside or outside environment changes. It can also affect the progress of cell growth, proliferation, apoptosis and
autophagy. Tumor cell obtains its peculiar energy metabolism, Warburg effect, for the coordination to the relative shortage of nutrition
and energy. The activation of AMPK disturbs tumor cell’peculiar energy metabolism, and exhibits close relation to the tumor
pathogenesis, development and metastasis. Non-small lung cancer (NSCLC) is a commom type of malignant tumor, containing the
characteristics of the general malignant tumor. In recent years, the studies of AMPK in NSCLC have indicated that AMPK and its related
signal molecules such as LKB1, PI3K/AKT, CaMKK-beta, PTEN and etc. have a tight connection to NSCLC. Activation of some signal
pathway and suppression of other pathway both show a significant antagonismtoward NSCLC. Thus AMPK and its related signals have a
hopeful prospect of function as a possible target for drug development in the treatment of NSCLC. |
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