| 张映 王静 胡玲琴 刘颖异 潘玉君.多胺及其代谢产物对脑缺血的影响与治疗[J].,2014,14(34):6762-6765 |
| 多胺及其代谢产物对脑缺血的影响与治疗 |
| The Effect of Polyamines and its Metabolic Products in CerebralIschemia and Therapy |
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| DOI： |
| 中文关键词: 多胺 代谢产物 脑缺血 神经毒性作用 |
| 英文关键词: Polyamine Metabolic products Cerebral ischemia Neurotoxic role |
| 基金项目:黑龙江省教育厅海外学人科研资助项目（1155h005）；哈尔滨医科大学附属第一医院科研基金（R08-002） |
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| 中文摘要: |
| 多胺(Polyamines)是直链多价阳离子碱性胺，包括腐胺(putrescine，PUT) ，精胺(spermine，SPM)，精脒(spermidine，SPD)等。广
泛存在于各种组织细胞内，是一种代谢调控物质，在细胞的增殖分化中起着重要作用。脑梗死是成人致残、致死的最常见疾病之
一。研究表明，脑缺血后，多胺及其代谢产物增加，能引起梗死面积的扩大及缺血半暗带神经细胞的坏死。其潜在机制尚不明确，
可能与缺血后多胺代谢产生腐胺，3-氨基丙醛（3-amidopropanal 3-AP），过氧化氢及丙烯醛等的活性物质有关，它们参与开放钙离
子通道，破坏血脑屏障，形成血管源性脑水肿及缺血再灌注性神经性损伤等病理过程。而抑制多胺代谢可有效地缓解缺血后多胺
及其代谢产物增加引起的神经损伤。本文就多胺及代谢产物对脑缺血的神经毒性作用及药物抑制多胺代谢治疗脑梗死做一综
述。 |
| 英文摘要: |
| Polyamines, such as putrescine, spermidine and spermine, are organic polycations that widely distribute in the body
and play crucial roles for the regulation of cell division. Cerebral infarction is one of most common causes of death and is the leading
cause of disability among adults in the world. Polyamines and metabolic products levels change dramatically following cerebral
ischaemia, leading to neuronal injury in the penumbra following cerebral ischemia and expansion of the area of infarcted tissue. Although
the precise mechanism is unclear, the presence of reactive aldehydes produced through polyamine metabolism, such as putrescine, H2O2,
3-aminopropanal and acrolein, have been shown to correlate with the incidence of disturbance of cellular calcium ion channels,
disruption of blood-brain barrier, formation of vasogenic brain edema and reperfusion injury. Regulation of the polyamine metabolic
pathway, therefore, may have the potential to limit injury following cerebral ischemia. The article reviews the neurotoxic role of
polyamines and manipulated polyamine metabolismin efforts to ameliorate its deleterious effects following cerebral ischemia. |
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