| 孙梓程 崔滨滨 刘彦龙 张干 李景文 韩鹏.大肠癌组织中联合检测USP22 和BMI-1表达的临床意义[J].,2014,14(33):6432-6436 |
| 大肠癌组织中联合检测USP22 和BMI-1表达的临床意义 |
| Clinical Significance of the Expression of USP22 and BMI-1in Colorectal Cancer |
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| DOI： |
| 中文关键词: USP22 BMI-1 大肠癌 临床病理特征 预后 |
| 英文关键词: USP22 BMI-1 Colorectal cancer Clinicopathological characteristics Prognosis |
| 基金项目:国家自然基金面上项目（81272704）；黑龙江省自然科学基金面上项目（D201149） |
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| 中文摘要: |
| 目的：探讨大肠癌组织中联合检测USP22 和BMI-1 表达的临床意义。方法：应用定量RT-PCR 检测82 例大肠癌手术切除
标本及相应的癌旁组织中USP22 及BMI-1 mRNA 的表达水平，并分析其表达的差异，研究其表达水平与大肠癌患者临床病理特
征及预后的关系。结果：USP22、BMI-1 mRNA在大肠癌及癌旁组织中均可被检出，大肠癌组织中USP22、BMI-1 mRNA的相对表
达水平均显著高于癌旁组织(P<0.01)，且二者之间呈显著正相关(r=0.708，P<0.01)。USP22、BMI-1 mRNA的高表达均与大肠癌的
美国癌症分期联合委员会(AJCC)分期密切相关(P<0.01)。COX 回归分析显示USP22 及BMI-1的共表达可作为大肠癌患者预后的
独立预测因素(P<0.01)。结论：USP22 和BMI-1 的共同激活可促进大肠癌的进展，并预示预后不良。 |
| 英文摘要: |
| Objective:To investigate the clinical significances of expression of USP22 and BMI-1 in colorectal cancer (CRC).Methods:The mRNA level of USP22, BMI-1 in 82 matched samples comprising primary CRC and paired non-cancerous mucosa were
detected and compared by quantitative RT-PCR. Then the correlation of mRNA level of USP22, BMI-1 with the clinicopathological
characteristics and prognosis of patients with CRC were analyzed.Results:The mRNA expression of USP22 and BMI-1 were
significantly up-regulated fromnon-cancerous mucosa to primary carcinoma (P<0.0001). There was positive and significant relationship
(r=0.708, P<0.0001) between the two genes. Increased mRNA expression of USP22 and BMI-1 were associated with certain
clinical-pathologic variables such as advancing AJCC stage (P<0.0001). Overexpression of USP22 and BMI-1 remained a
statistically-significant prognostic marker in the Cox regression analysis.Conclusion:The co-activation of USP22 and BMI-1 may
associate with the progression and prognosis of CRC. |
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