| 薛宝瑶 谢婷婷 姜霞 徐小博 于月成.趋化因子SD-1 及其受体CXCR4 在卵巢癌中的研究进展[J].,2014,14(31):6168-6170 |
| 趋化因子SD-1 及其受体CXCR4 在卵巢癌中的研究进展 |
| Progress of Chemokine SD-1 and Its Receptor CXCR4 in Ovarian Cancer |
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| DOI： |
| 中文关键词: CXCL12 CXCR4 卵巢癌 |
| 英文关键词: CXCL12 CXCR4 Ovarian cancer |
| 基金项目:国家自然科学基金项目(30872740) |
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| 中文摘要: |
| 基质细胞衍生因子-1（Stromal cell derived factor-1, SDF-1）是CXC 趋化因子家族的重要成员,系统命名为CXCL12，能与它
的唯一受体CXC趋化因子受体-4（CXC chemokine receptor-4，CXCR4）形成CXCL12-CXCR4生物学轴，CXCL12-CXCR4 生物学
轴在肿瘤生长、侵袭、转移过程中发生重要作用。到目前为止，已发现CXCL12-CXCR4 在卵巢癌、胰腺癌、肝癌等多种肿瘤组织中
表达。然而，国内目前还没有关于CXCL12-CXCR4与卵巢癌关系的相关综述，本文将从趋化因子CXCL12 及其受体CXCR4，
CXCL12/CXCR4 轴与卵巢癌细胞系实验研究，CXCL12-CXCR4 轴与卵巢癌的临床研究，CXCL12/CXCR4 与卵巢癌预后，
CXCL12/CXCR4 与卵巢癌治疗展望等五个方面对CXCL12-CXCR4 生物轴与卵巢癌的关系，及其在卵巢癌治疗中的应用展开综
述。 |
| 英文摘要: |
| SDF-1(Stromal cell derived factor-1), system named as CXCL12, is an important member of CXC chemokine family,
which could form CXCL12-CXCR4 biological axis with its only receptor CXCR4 (CXC chemokine receptor 4). CXCL12-CXCR4
biological axis played an important role in tumor growth, invasion and metastasis. So far, it was found that CXCL12-CXCR4 was
expressed in various tumor tissues, such as ovarian cancer, pancreatic cancer, and liver cancer. However, there is no domestic reviews on
the relationship between CXCL12-CXCR4 and ovarian cancer. In this article, the relationship of CXCL12-CXCR4 biological axis and
ovarian cancer, and its application in the treatment of ovarian cancer were reviewed from the following five aspects: CXCL12 and
CXCR4; the role ofCXCL12/CXCR4 axis in the experimental study of ovarian cancer cell lines; CXCL12/CXCR4 axis and clinical research
on ovarian cancer; role of CXCL12/CXCR4 in ovarian cancer prognosis; and role of CXCL12/CXCR4 in ovarian cancer treatment. |
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