| 刘永娟 李小静 刘秀萍 舒维清 腾昊骅 杨菊 武景波.235 例浸润性乳腺癌中P53、ER的表达及其相关性探讨[J].,2014,14(31):6079-6082 |
| 235 例浸润性乳腺癌中P53、ER的表达及其相关性探讨 |
| The Expression and Relationship between ER and P53 Expression inInvasive Breast Carcinoma |
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| DOI： |
| 中文关键词: 浸润性乳腺癌 P53 雌激素受体 相关性 |
| 英文关键词: Breast invasive carcinoma Immunohistochemical index P53 ER |
| 基金项目:国家自然科学基金面上项目（81071813） |
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| 中文摘要: |
| 目的：分析浸润性乳腺癌中P53 和雌激素受体(estrogen receptor，ER)的表达及其与患者临床病理特征的关系和二者之间的
相关性，探讨其在浸润性乳腺癌发生发展中的作用。方法：收集我院2008 年至2013 年6 月收治的原发浸润性乳腺癌手术病例
235 例，采用免疫组化SP 法检测乳腺癌组织标本中P53 与ER的表达，分析其与患者临床病理特征的关系及二者之间的相关性。
结果：本组乳腺癌组织中P53 与ER 的阳性表达率分别为31.9 %及56.6 %，均显著高于癌旁正常组织(P<0.05)。乳腺癌组织中ER
的表达仅与患者的年龄有关，与TNM分期无关；而P53 的表达与患者的年龄和TNM 分期均无关，但P53 与ER 的表达呈显著负
相关(P<0.05，r=-0.174)。结论：P53 与ER 在浸润性乳腺癌中均呈高表达，且二者呈显著负相关。 |
| 英文摘要: |
| Objective:To analyze the correlation of ER, P53 expression with the clinicopathologic characteristics of patients with
invasive breast carcinoma and the correlation of ER expression with P53 expression, and to study the role of ER and P53in the
tumorigenesis and development of invasive breast carcinoma.Methods:A total of 235 female cases with breast invasive carcinoma were
retrieved from the Department of Pathology Shanghai No.5 Hospital from 2008 to 2013. The immunohistochemical SP method was used
to detect the expression of ER and P53 in postoperative paraffin blocks. The correlation was analyzed between the clinicopathologic
characteristics and ER, P53 expression, and between the ER expression and P53 expression. The expression of ER and P53 was observed
inpericarcinous normal tissue.Results:The positive expression rates of ER and P53 were 56.6%and 31.9%in the 235 cases, which were
both significantly higher than those of the adjacent normal breast tissue. The positive expression rate of P53 was negatively correlated
with ER expression in the 235 cases (P<0.05, r= -0.174). Compared with the pericarcinousnormal tissue, the positive expression rate of
the ER and P53 were significantly higher in the carcinoma tissue (P<0.05).Conclusion:The expression of P53 and ER were both
upregulated in invasive breast carcinoma, which were negatively correlated and may play an important role in the tumorigenesis of
invasive breast carcinoma. |
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