| 王磊 胡沙沙 郭菲菲 孙向荣 韩晓华 公衍玲 刘虹 杨南 徐珞.Ghrelin 对改善心衰大鼠左室功能紊乱的作用研究[J].,2014,14(31):6022-6027 |
| Ghrelin 对改善心衰大鼠左室功能紊乱的作用研究 |
| The Effects of Ghrelin on Left Ventricular Dysfunction Improving inRats with Heart Failure |
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| DOI： |
| 中文关键词: 慢性心力衰竭 Ghrelin 左室功能紊乱 |
| 英文关键词: Chronic heart failure Ghrelin Left ventricular dysfunction |
| 基金项目:国家自然科学基金项目（31071014；81100260；81270460；81300281）；山东省医药卫生科技发展计划项目（2013WS0263）；
青岛市科技局项目（13-1-4-170-jch） |
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| 中文摘要: |
| 目的：慢性心力衰竭（CHF）患者终末期阶段常发生左室（LV）重塑和心脏性恶病质，有研究称Ghrelin 可能对CHF LV 功能
和能量代谢产生保护作用。本文旨在探讨Ghrelin 对CHF大鼠LV 功能紊乱和心源性恶病质的作用。方法：建立左冠状动脉结扎
术和假手术组，手术后4 周，给予大鼠Ghrelin 或生理盐水3周。用超声心动图和心脏导管术监测结果。结果：与给予安慰剂组相
比，用Ghrelin 治疗的CHF和假手术组，血浆GH和胰岛素样生长因子1 明显升高(t=1.49，t=0.71，P<0.05)。与Sham-Placebo 组相
比，CHF-Placebo 组大鼠体重明显减轻(t=2.18，P<0.05)。然而与CHF-Placebo 组相比，CHF-Ghrelin 组大鼠，体重(t=3.89，P<0.05)，
心输出量(t=3.28，P<0.05)，LV dP/dtmax(t=3.90，P<0.05)明显增加。Ghrelin 增加了CHF大鼠心脏舒张压，抑制LV 扩大，增加LV 缩
短分数。结论：长期注射Ghrelin 可改善CHF大鼠LV 功能紊乱，减缓LV 重构和心脏性恶病质的发展，有望为CHF的治疗提供新
的途径和方法。 |
| 英文摘要: |
| Objective:Chronic heart failure (CHF) patients in end-stage often appear left ventricular (LV) remodeling and cardiac
cachexia. It is reported that ghrelin had protecting effect on CHF LV function and energy metabolism. The purpose of this study is to
explore the effects of ghrelin on LV dysfunction and cardiac cachexia in CHF rats.Methods:Ligation of the left coronary artery or sham
operation was performed; 4 weeks after surgery, ghrelin (100 mg/kg SC BID) or saline was administered for 3 weeks. Echocardiography
and cardiac catheterization were performed.Results:Serum GH and insulin-like growth factor-1 were significantly higher in both CHF
and shamrats treated with ghrelin than in those given placebo (P<0.05 for both). CHF rats given placebo showed an impaired increase in
body weight compared with sham rats given placebo (P<0.05). CHF rats treated with ghrelin, however, showed a significantly greater
increase in body weight than those given placebo ( 110 %versus 13 %, P<0.05). They showed significantly higher cardiac output (P<0.
05) and LV dP/dtmax (P<0.05) than CHF rats given placebo. Ghrelin increased diastolic thickness of the noninfarcted posterior wall,
inhibited LV enlargement, and increased LV fractional shortening in CHF rats.Conclusion:Chronic administration of ghrelin can
improve LV dysfunction and slow down the development of LV remodeling and cardiac cachexia in rats with CHF. Ghrelin is expected
to become a new method for the treatment of CHF. |
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