| 乔聪聪 宁婉辰 何艳艳 石丽萍 贾树芳 王丽.TGF-beta1 基因rs200482214 位点多态性与黑龙江省汉族人群慢性牙周炎的相关性研究[J].,2014,14(30):5855-5858 |
| TGF-beta1 基因rs200482214 位点多态性与黑龙江省汉族人群慢性牙周炎的相关性研究 |
| Association between TGF-beta1 rs200482214 Polymorphismand Susceptibility to Chronic Periodontitis in Chinese Hanin Heilongjiang |
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| DOI： |
| 中文关键词: 慢性牙周炎 基因多态性 转移生长因子beta1 |
| 英文关键词: Chronic periodontitis Polymorphism TGF-beta1 |
| 基金项目:黑龙江省青年科学基金项目（QC2010008） |
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| 中文摘要: |
| 目的：探讨转移生长因子beta1(transforming growth factor beta-l，TGF-beta1)位点rs200482214 基因多态性与黑龙江省汉族人群慢
性牙周炎的易感性的相关性。方法：选取2012 年3 月至2013 年7 月在哈尔滨医科大学附属口腔医院牙周科就诊的135 例轻、
中、重度慢性牙周炎汉族患者(牙周炎组)和108 例汉族健康对照者(健康对照组)作为研究对象，基因组DNA 来自口腔颊粘膜拭子，采用多重单碱基延伸SNP 分型技术(Multiplex SNaPshot technique)对所有受试者TGF-beta1 基因rs200482214位点进行检测，比较两组间此位点基因型分布和等位基因频率的差异。结果：(1)TGF-beta1基因rs200482214 位点各基因型(GG、GA、AA)分布均符合
Hardy-Weinberg 遗传平衡定律(P>0.05)；(2)TGF-beta1 基因rs200482214位点GG、GA、AA在牙周炎组和健康对照组的分布频率分别为61.5 %、30.4 %、8.1 %和63.0 %、28.7 %、8.3 %，两组人群基因型分布频率差异无统计学意义(P>0.05)；等位基因G、A 在牙周
炎组和健康对照组分布频率分别为76.7 %、23.3 %和77.3 %、22.7 %，两组人群的等位基因分布频率差异亦无统计学意义
(P>0.05)。结论：TGF-beta1 位点rs200482214 基因多态性与黑龙江省汉族人群慢性牙周炎的易感性不具有相关性。 |
| 英文摘要: |
| Objective:To investigate the association between TGF-beta1 rs200482214 polymorphism and susceptibility to Chronic
periodontitis in Chinese Han in Heilongjiang.Methods:We performed a case-control study on 135 mild, moderate, severe chronic
periodontitis patients and 108 healthy controls. Genomic DNA from oral mucosa of two groups was got. Polymorphism of TGF-beta1 gene
was analyzed using the Multiplex SNaPshot technique, the differences of the genotype and allele frequencies were calculated and
analyzed.Results:(1)All genotypes distribution of the TGF-beta1 rs200482214 polymorphismwere in Hardy-Weinberg equilibrium in both
the cases and the controls; (2)TGF-beta1 rs200482214 GG, GA, and AA genotype frequencies were 61.5 %, 30.4 % and 8.1 % in case
samples, and 63.0 %, 28.7 % and 8.3 % in control samples, respectively, two groups genotype frequencies distribution were not
significantly different (P>0.05); The allele G, A distribution frequencies were 76.7 %, 23.3%in the periodontitis group and 77.3 %, 22.7
% in the control group, no significant difference was found in the distribution of allele frequencies between two groups (P>0.05).Conclusion:TGF-beta1 rs200482214 polymorphism may be not association with the susceptibility to Chronic Periodontitis in Chinese Han
in Heilongjiang. |
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