| 栗颖利 王克华 李江 邢新 陈辉.腋臭患者大汗腺中ApoD和AR 的表达水平与气味强度间的关系[J].,2014,14(30):5837-5840 |
| 腋臭患者大汗腺中ApoD和AR 的表达水平与气味强度间的关系 |
| Relationship between ApoD and AR in the Apocrine Sweat Glands and OdorIntensity in Axillary Osmidrosis Patients |
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| DOI： |
| 中文关键词: 腋臭 大汗腺 气味 ApoD AR |
| 英文关键词: Axillary osmidrosis Apocrine sweat glands Odor Apolipoprotein D(ApoD) Androgen receptor(AR) |
| 基金项目:国家自然科学基金项目（81271579） |
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| 中文摘要: |
| 目的：明确大汗腺组织中ApoD和AR的表达水平与腋臭患者散发出气味间的关系，阐明两者在腋臭发病中的作用，为腋臭
的临床治疗和干预奠定基础。方法：收集在我院整形外科就诊的腋臭病人腋下皮肤组织标本41 例。手术前由3 名医生共同判断
患者腋下气味强度，按照能在≤ 1 m、≤ 3 m、≤ 5 m距离闻及气味把患者分为轻、中、重三组。随机抽取各组标本组织块进行
RT-PCR 检测，测定ApoD 和AR 在大汗腺组织中的含量。结果：根据气味强度判定标准，轻、中和重3 组患者人数分别为：7 人、11
人和23 人。按照AB 7500 Real-Time PCR 系统分析结果所示ApoD 相对表达量的等级与气味强度之间有线性关系(P<0.05)，
ApoD相对表达量的等级随着气味强度的增加而升高；AR 相对表达量的等级与气味强度之间有线性关系(P＜0.05)，随着气味强
度的增加而升高。结论：ApoD 和AR 的表达量与腋臭气味强度之间有着密切的联系。进一步证实AR可调节大汗腺组织ApoD 的
表达，为明确腋臭的发病机制提供了理论依据。 |
| 英文摘要: |
| Objective:To study the relation of ApoD/AR and odor strength in apocrine sweat gland of axillary osmidrosis and to
confirmthe effect in the pathogenesis of axillary osmidrosis so as to establish the theoritical basis for the pathogenesis of disease.Methods:We collected armpit skin tissue 41 samples of axillary osmidrosis group in our hospital. Three doctors smell armpit odor in different distances(
1 m, 3m and 5 m). The extent of the osmidrosis were classified into mild, middle and severe degree correspondent to the unpleasant
odor obviously smelled at 1, 3 and 5 meters. Then we detected the content of ApoD and AR through Real-time PCR. Statistical analysis
and processing were done later.Results:There were 7 patients in mild degree, 11 patients in middle degree and 23 patients in severe
degrees. The Real-Time PCR showed that there was relationship between the degree of relative expression of ApoD/AR and odor
strength(P<0.05). The degree of relative expression of ApoD increased with the increase of odor strength.Conclusion:There was a direct
relationship between the degree of relative expression of ApoD/AR and odor strength. It may play a crucial role in the process of axillary
osmidrosis odor that should be confirmed in the future. |
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