| 郑丽新 赵明 王玉 苏迪 郭晓东.高凝状态对非小细胞肺癌患者深静脉血栓形成的影响[J].,2014,14(29):5699-5701 |
| 高凝状态对非小细胞肺癌患者深静脉血栓形成的影响 |
| Effect of the Hypercoagulability on the Formation of Deep Vein Thrombosisin Patients with Non-small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 高凝状态 非小细胞肺癌 静脉血栓形成 临床意义 |
| 英文关键词: Hypercoagulability Non-small-cell lung cancer Deep vein thrombosis Clinical significance |
| 基金项目:国家自然科学基金青年科学基金项目(81301239) |
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| 中文摘要: |
| 目的：探讨高凝状态对非小细胞肺癌患者深静脉血栓形成的影响，为临床治疗提供依据。方法：选择2010 年5 月至2013年
6 月在我院接受治疗的非小细胞肺癌患者195 例，记录患者姓名、年龄、性别、病理类型、手术、临床分期、放化疗、伴随疾病、身体
状况评分(eastern cooperative oncology group, ECOG 评分)及是否发生血栓等指标。调查入选患者的高凝状态指标，包括血小板
(platelet，PLT)、纤维蛋白原(fibrinogen，Fib)、血浆凝血酶原时间(plasma prothrombin time，PT)、凝血酶时间(thrombin time，TT)、活化
部分凝血活酶时间(activated coagulation time of whole blood，APTT)和D-二聚体(D-dimer)。结果：195 例非小细胞肺癌患者中，PLT
高于正常上限的有42 例(21.5%)，FIB升高的有78 例(40%)，TT 延长的有12 例(6.2%)，PT 缩短的有45 例(23.1%)，D-D升高的有
60 例(30.8%)，APTT 缩短的有15 例(7.7%)。两项指标异常的有62 例(31.8%)，FIB 和D-D 升高的有32 例(16.4%)；三项指标异常的
有27 例(13.8%)，PLT、FIB及D-D 升高的有15 例(7.7%)；四项指标异常的有5 例(2.6%)，PLT、FIB 及D-D 升高，而PT 缩短的有5
例(2.6%)。所有患者各凝血指标中位值PLT 为219× 109/L，FIB为3.6 g/L，TT 为13.4 s，PT 为10.8 s，D-D 为0.341 mg/L，APTT 为
29.7 s。结论：高凝状态对非小细胞肺癌患者深静脉血栓形成具有重要的促进作用，应受到临床的重视。 |
| 英文摘要: |
| Objective:To investigate the high coagulation state on the formation of deep vein thrombosis for patients with
non-small cell lung cancer so as to provide a basis for clinical treatment.Methods:195 patients with non-small cell lung cancer who were
treated in our hospital fromMay 2010 to June 2013 were selected. Then the clinical data of patients such as the name, the age, the gender,
the pathological type, surgery, radiation and chemotherapy, the clinical stages, with disease and health score (ECOG) and the indexes of
blood clots were recorded. The high coagulation state indicators, including the PLT, the fibrinogen (Fib), the plasma prothrombin time,
the thrombin time (TT), the activated partial thrombin time (APTT) and the D dimer (D-D) of patients were detected and analyzed.Results:Among the 195 patients with non-small cell lung cancer, 42 cases (21.5%) with the PLT that higher than the normal, 78 patients
(40%) with the FIB elevated, TT extended in 12 cases (6.2%), PT a shortened in 45 cases (23.1%), D-D rising in 60 cases (30.8%), APTT
shortening in 15 cases (7.7%). Two indicators of abnormal in 62 patients (31.8%), FIB and D-D rise in 32 cases (16.4%); There are three
indicators of abnormal 27 cases (13.8%), PLT, FIB and D-D rising in 15 cases (7.7%). There were four indicators of abnormal in 5 cases
(2.6%), PLT, FIB and D-D higher, and PT lower in 5 cases (2.6%). The median blood coagulation indexes were: PLT 219× 109/L, FIB
3.6 g/L, TT 13.4 s, PT 10.8 s, D-D 0.341 mg/L, APTT 29.7 s.Conclusion:High coagulation state plays an important role in the
promotion of deep vein thrombosis for patients with the non-small-cell lung cancer that should be brought to the attention in the clinical. |
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