| Objective:To investigate the clinical significance of the combind detection of cardiac troponinⅠ (cTnⅠ ), creatine
kinase isoenzyme-MB (CK-MB), myoglobin(MYO) and beta-type natriuretic peptide (BNP) in the diagnosis of acute coronary syndrome
(ACS).Methods:The serum of 76 patients with definite diagnosis of ACS (ACS group), 32 patients with definite diagnosis of stable
angina (SA group) and 35 healthy controls (control group) were detected for cTnⅠ, CK-MB, MYO and BNP levels by immuni-chemical
luminescence method. The sensitivity and specificity of 4 paraimeters were evaiuated by receiver operating characteristic (ROC) curve.Results:The levels of cTnⅠ, CK-MB, MYO and BNP of ASC group were（9.27± 7.25）ug/L,（239.50± 213.27）ng/ml, (37.06± 21.60)
ng/ml,（632.11± 293.20）pg/ml respectively and those of AS group were（1.32± 0.57）ug/L, 63.34± 31.02）ng/ml,（19.48± 8.04）ng/ml,
（125.20± 6.57）pg/ml and those of control group were（0.17± 0.06）ug/L,（30.02± 15.23）ng/ml,（14.06± 3.19）ng/ml,（47.52± 21.30）
pg/ml. The levels of cTnⅠ, CK-MB, MYO and BNP showed statistical difference between ACS group and health controls(P＜0.01), and
its positive rates was higher compored with those in ACS group. The area under ROC curve (AUC) of cTnⅠ (0.917± 0.025), was
significantly higher than that of conventional BNP (0.823 ± 0.031, P=0.037). The sensitivity of combined detection was 92.3%in ACS
diagnosis, which was higher significantly than that the individual detection (86.0%).Conclusion:The combined determination of the
serumcTnⅠ, CK-MB, MYO and BNP has complementation significance in doagnosis of myccardial ischemia and myocoardial injury. |
