| 汪学翠 刘红梅 陈思文 付婷 王翎.髓系细胞触发受体-1 研究进展[J].,2014,14(27):5387-5390 |
| 髓系细胞触发受体-1 研究进展 |
| Development of Triggering Receptor Expressed on Myeloid Cells-1 |
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| DOI： |
| 中文关键词: 髓系细胞表达的触发受体-1 炎症反应 肿瘤预后 |
| 英文关键词: TREM-1 Inflammatory response Prognosis of tumor |
| 基金项目:国家自然科学基金项目（30330540） |
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| 中文摘要: |
| 摘要：髓系细胞表达的触发受体1(triggering receptor expressed on myeloid cells-1，TREM-1)是主要表达于巨噬细胞、中性细胞等的
表面受体蛋白，它属于免疫球蛋白超家族的成员，主要由赖氨酸残基的跨膜结构域、V 型Ig样胞外结构域和缺乏信号基序的胞浆
结构域等三个部分组成。TREM-1 分子在感染性疾病中发挥重要作用，通过其和细胞外受体蛋白DAP-12 结合，引起下游信号通
路活化，导致多种炎症介质的分泌，具有预激和诱导炎症反应的作用，对感染性疾病的诊断起到重要作用。但最近研究显示
TREM-1 不仅在感染性组织中表达增高，在非感染性炎症、结缔组织及肿瘤组织中也有增高表现，本文就TREM-1 最新研究进展
做一综述。 |
| 英文摘要: |
| Triggering receptor expressed on myeloid cells 1 is mainly expressed on the surface receptor proteins of macrophages
and neutral, which belongs to superfamily of Immunoglobulin, It contains the membrane structure domain of lysine residues, the form of
V extracellular domain structure and cytoplasm structure domain which is less than signal motif. TREM-1 plays an important role in the
infectious disease, which combines with extracellular receptor proteins DAP - 12, cause downstreamsignaling pathway activation and the
secretion of a variety of inflammatory mediators, pre-excitation syndrome and induced inflammation. It plays an important role in
infectious diseases. The latest research suggests that TREM-1 is not only expressed in infectious diseases, but also belongs to
non-infectious inflammation, connective tissue and tumor tissue. This text introduces the latest research progress of TREM-1. |
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