| 李晓亮 肖燎原 徐志飞.胶质瘤相关癌基因蛋白在肿瘤发生中的作用[J].,2014,14(27):5384-5386 |
| 胶质瘤相关癌基因蛋白在肿瘤发生中的作用 |
| The Roll of Glioma-Associated Oncogene1(Gli) in Tumorigenesis |
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| DOI： |
| 中文关键词: 胶质瘤相关癌基因蛋白 Hedgehog 信号通路 肿瘤 |
| 英文关键词: Gli Hedgehog signal pathway Tumour |
| 基金项目: |
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| 中文摘要: |
| 摘要：胶质瘤相关癌基因蛋白（glioma-associated oncogene1, Gli）是Hedgehog(Hh)信号通路的转录因子, 定位于细胞核和细胞浆，
将信号传送至核内。脊椎动物中已鉴定出3 个成员，分别为Gli 1、Gli2 和Gli3，该蛋白家族成员只有在维持全长时才具有转录激
活子的功能，羧基端被蛋白酶体水解后，就形成了转录抑制子。近年来，Gli 与肿瘤的关系日益受到人们的重视, 以前普遍认为的
Gli目的基因的调控和Gli蛋白的转录后修饰是通过Hh 通路实现受到挑战，越来越多的研究证明有许多非经典机制可以不通过
Hh 通路来调节Gli 目的基因的表达。Gli 研究将有助于我们对肿瘤的认知和治疗。 |
| 英文摘要: |
| Glioma-associated oncogene1 protein (Gli) is the transcriptional factor of Hedgehog (Hh) signal pathway, which
located in cytoplasm and cell nucleus, and plays the roll of transmit signal into nucleus. Vertebratas has identified three members of Gli,
they are Gli1, Gli2 and Gli3 respectively. The protein family members, only when they maintain the full-length, activator of transcription;
and when the carboxy-terminal are proteasomed a transcriptional repressor. In recent years, increasingly attention has been paid to the
relationship between Gli and tumour. It has been widely accepted that Gli's target gene regulation and Gli's post-transcriptional
modification is by Hh pathway, but it be challenged. A growing number of studies have shown that there were many non-classical
mechanismthat can not pass the Hh pathway to regulate the expression of Gli's target gene. Doing researches on Gli will help us to kown
and treatment tumours. |
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