| 王永红 冉茂娟 姜艳 王剑波 曾成鸣.槐角黄酮栓抗炎、止血、抗溃疡作用的实验研究[J].,2014,14(27):5247-5252 |
| 槐角黄酮栓抗炎、止血、抗溃疡作用的实验研究 |
| Study on Anti-Inflammatory, Hemostasis and Anti-Ulcerative Effects of Fructus Sophorae Flavonoids Suppository |
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| DOI： |
| 中文关键词: 槐角 总黄酮 栓剂 抗炎 止血 抗溃疡 |
| 英文关键词: Fructus Sophorae Flavonoids Suppository Anti-inflammation Anti-ulceration Hemostasis |
| 基金项目:陕西省中医药管理局基金课题(2009ZY015) |
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| 中文摘要: |
| 目的：研究槐角黄酮栓的抗炎、止血、抗溃疡作用。方法：从中药槐角中提取总黄酮，与脂肪酸甘油酯混合后用热融法制成栓
剂。采用小鼠耳廓肿胀法、滤纸肉芽肿法、腹腔毛细血管通透性试验和角叉菜胶致大鼠足跖肿胀法观察槐角黄酮栓的抗炎作用；
通过玻璃毛细管法和断尾法测定小鼠出、凝血时间，评价槐角黄酮栓的止血效果。复制大鼠直肠损伤模型，直肠给药治疗，观察伤
口愈合情况并HE 染色，评价槐角黄酮栓的促愈合作用。结果：槐角黄酮栓具有明显的抗炎、抗溃疡作用，并能缩短小鼠出、凝血时
间，提高直肠创面愈合率。结论：槐角黄酮栓制备工艺简单，具有较好的抗炎、止血、抗溃疡作用。 |
| 英文摘要: |
| Objective:To study the effect of Fructus Sophorae Flavonoids Suppository (FSFS) on anti-inflammator, hemostasis
and anti-ulcerative.Methods:The total flavones was extracted from Chinese traditional medicine Fructus Sophorae, which was mixed
with adeps solidus to prepare the suppository by the method of hot-melting. The anti-inflammatory effects of FSFS were determined by
using the experiment of swelling of ear induced by xylene, granuloma induced by cotton ball, capillary permeability of abdominal cavity
induced by acetic acid and hind paw edema induced by carrageenin in mice. The hemostatic efficacy of FSFS and the coagulation time
were measured by the glass capillary method, and the bleeding time was measured by the tail-cutting method, respectively. Rat anorectal
wound model was established, and the healing effect of FSFS was evaluated by HE staining.Results:The FSFS has distinct anti-inflammatory, anti-ulcerative effects, as well as obviously shorten the coagulation time and bleeding time of mice severed tail, and increase anorectal wound healing proportion.Conclusion:Preparation process of FSFS is simple, and showed good anti-inflammatory,
hemostasis and anti-ulcerative effects. |
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