| 赵强 庞海林 马宁强 周菁 张峰 刘乐乐 张贺龙.埃兹蛋白的表达与非小细胞肺癌转移的关系研究[J].,2014,14(27):5235-5237 |
| 埃兹蛋白的表达与非小细胞肺癌转移的关系研究 |
| The Study of Relationship between Ezrin Protein Expression and NSCLCMetastasis |
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| DOI： |
| 中文关键词: 埃兹蛋白 非小细胞肺癌 转移 |
| 英文关键词: Ezrin protein Non-small cell lung cancer Metastasis |
| 基金项目:国家自然科学基金项目（30973488） |
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| 中文摘要: |
| 目的：探究埃兹蛋白（Ezrin）的表达与非小细胞肺癌转移的关系。方法：通过免疫组化检测Ezrin 在有无转移的非小细胞肺癌
组织中的表达差异，通过细胞免疫组化、western-blot、RT-PCR 检测Ezrin 在不同转移潜能肺癌细胞系中的表达差异，通过
transwell 考察Ezrin 对不同转移潜能癌细胞侵袭和迁移能力的影响。结果：Ezrin 蛋白在有转移的非小细胞肺癌组织中的表达水平
明显高于无转移的肺癌组织，在高转移潜能肺癌细胞系中的表达高于低转移潜能细胞系，受抑制时会削弱高转移潜能肺癌细胞
的迁移和侵袭能力，过表达时会增强低转移潜能肺癌细胞的侵袭和迁移能力。结论：Ezrin 可能在非小细胞肺癌及其转移中发挥重
要作用。 |
| 英文摘要: |
| Objective:To investigate the relationship between Ezrin protein expression and Non-small cell lung cancer (NSCLC)
metastasis.Methods:The different expressions of Ezrin in NSCLC tissues with and without metastasis were detected by
immunohistochemistry. The different expressions of Ezrin in Non-small cell lung cancer cells with different metastasis potential were
studied by immunohistochemistry, western-blot and RT-PCR. The effects of Ezrin to invasion and migration abilities of cancer cells with
different metastasis potential were studied by transwell.Results:The expression of Ezrin protein in Non-small cell lung cancer tissues
with metastasis was higher than that without metastasis. The expression of Ezrin in lung cancer cells with high metastasis potential was
higher than that with low metastasis potential. The invasion and migration abilities of cancer cells with high metastasis potential
weakened when Ezrin inhibited, while the abilities of cancer cells with low metastasis potential strengthened when Ezrin overexpressed.Conclusion:Ezrin may play an important role in NSCLC and its metastasis. |
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