| 吴锋 杨幼林 房彧 张慧超 牛思佳.幽门螺杆菌感染与胃癌相关性的研究进展[J].,2014,14(26):5198-5200 |
| 幽门螺杆菌感染与胃癌相关性的研究进展 |
| Research Progress on the Correlation of H.pylori infection with Gastric Cancer |
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| DOI： |
| 中文关键词: 幽门螺杆菌 胃癌 相关性 根除治疗 |
| 英文关键词: Gastric cancer Correlation Eradication therapy |
| 基金项目: |
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| 中文摘要: |
| 胃癌(gastric cancer)是人类最常见的恶性肿瘤之一，是全球性的医疗难题，其病因尚未完全明确。自20 世纪80 年代初两位
澳大利亚科学家Marshall 和Warren 首先从胃黏膜中分离出幽门螺杆菌( Heliobacter pylori,Hp)至今， Hp与胃癌的关系为人们所
关注。经过多年的研究，人们逐渐接受了Hp感染为胃癌发生发展的重要因素，大多数学者认为根除治疗Hp可以降低胃癌发生的
风险。然而，近年来随着研究的不断深入，一些研究报道Hp根除治疗并不能预防胃癌的发生发展，也不能降低胃癌的发生率。胃癌的发病机制错综复杂， 感染作为单一致病因素如何引起胃癌的发生目前尚未阐述清楚。本文旨在对感染与胃癌相关性的研究进展做一综述。 |
| 英文摘要: |
| Gastric cancer was one of the most common malignant tumors in humans and also a global medical problem, the pathogeny of which was not yet clear. The relationship between and gastric cancer was started to atrract the attention when two
Australian scientists Marshall and Warren isolated (Helicobacter pylori,Hp ) from the gastric mucosa firstly in eraly 1980s. After years of research, people gradually accepted the opinion that helicobacter pylori infection played an significant role in the development of gastric
cancer, and most scholars believed that Hp eradication therapy could reduce the risk of gastric cancer. However, with the deepening of
research, several studies reported that Hp eradication therapy could not prevent the development of gastric cancer and could not reduce
the incidence of gastric cancer in recent years. Due to the complexed pathogenesis of gastric cancer, it was hard to explain clearly how Hp
infection as one single pathogenic mechanism caused the gastric cancer. This article was aimed to review the research progress on the
correlation of Hp with gastric cancer. |
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