| 石亚玲 刘丽儿 杨月勤 陈伟辉 梁开艳.血小板参数、hs-CRP 与免疫球蛋白联合检测对肝炎患者的临床意义[J].,2014,14(25):4954-4657 |
| 血小板参数、hs-CRP 与免疫球蛋白联合检测对肝炎患者的临床意义 |
| Clinical Significance of Platelet Parameters, hs CRP and ImmunoglobulinJoint Detection in Patients with Hepatitis |
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| DOI： |
| 中文关键词: 肝炎 血小板参数 超敏C 反应蛋白 免疫球蛋白 联合检测 |
| 英文关键词: Hepatitis Platelet parameters Hypersensitive c-reactive protein Immune globulin Joint detection |
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| 中文摘要: |
| 目的：探讨和研究血小板参数、超敏C 反应蛋白(hs-CRP)与免疫球蛋白联合检测对肝炎患者的临床意义，为临床中肝炎患者
的诊治提供参考。方法：收集各种病毒性肝炎患者共156 例(急性肝炎组48 例、慢性肝炎组56 例、重型肝炎组24 例和肝硬化组
28 例)，选择40 例健康体检者作为对照组，对5 组研究对象的血小板参数(（血小板计数(PLT)、平均血小板体积(MPC)、血小板压
积(PCT)和血小板分布宽度(PDW)）、血清超敏C 反应蛋白和免疫球蛋白（IgA、IgG 和IgM）水平进行检测和测定，并对这些指标的
变化进行对比分析。结果：除重型肝炎组与肝硬化组的血小板计数(PLT)，慢性肝炎组与重型肝炎组的PCT，急性肝炎组、肝硬化组
与对照组3 组间的PDW 的差异无统计学意义外，任意两组之间的差异均有统计学意义（P＜0.05）；各组肝炎患者的hs-CRP 均比
健康对照组显著升高（P<0.01），且免疫球蛋白也较对照组差异有统计学意义。结论：肝炎患者的血小板参数、超敏C 反应蛋白
(hs-CRP)与免疫球蛋白水平可以提示肝炎病情的变化，三者的联合检测为指导肝炎患者的判断、治疗方案的选择和疗效评定提供
有一定的参考依据。 |
| 英文摘要: |
| Objective:To explore and research the clinical significance of platelet parameters, hypersensitive c-reactive protein (hs
- CRP) and immune globulin combined detection in patients with hepatitis, and provide a reference for clinical diagnosis and treatment of
patients with hepatitis.Methods:A total of 156 patients with various viral hepatitis (48 cases of acute hepatitis, 56 cases of chronic hepatitis,
24 cases of fulminant hepatitis and 28 cases of hepatocirrhosis) were selected, 40 cases of healthy patients undergoing physical examination
were chosen as control group. Platelet parameters, platelet count (PLT), mean platelet volume (MPC), platelet deposited (PCT)
and platelet distribution width (PDW), hypersensitive c-reactive protein and serum immunoglobulin (IgA, IgG, IgM) level of 5 groups
were detected and measured, and the changes in these indicators were analyzed.Results:Except for that there were no significant difference
in platelet count (PLT) between severe hepatitis group and liver cirrhosis group, in PCT between chronic of hepatitis group and severe
hepatitis group, in PDWamong 3 groups of acute hepatitis, liver cirrhosis group and the control group, the difference between any
two groups were statistically significant (P<0.05); hs-CRP of groups of patients with hepatitis were significantly higher than the control
group (P<0.01), and the difference in the immunoglobulin level were also statistically significant compared with control group.Conclusion:Platelet parameters, hypersensitive c-reactive protein (hs-CRP) and immunoglobulins levels of patients with hepatitis can indicate
hepatitis condition changes, the joint detection of these tree indicators can provide a certain reference for the diagnosis of hepatitis, the
choice of treatment and curative effect evaluation. |
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