| 刘真淋 付正英 安艳辰 程红梅.壳聚糖膜在治疗宫颈疾病中的降解时间与影响因素的研究[J].,2014,14(25):4816-4818 |
| 壳聚糖膜在治疗宫颈疾病中的降解时间与影响因素的研究 |
| Study on Degradation Time and Influencing Factors of Chitosan Membranein the Treatment of Cervical Diseases |
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| DOI： |
| 中文关键词: 壳聚糖 膜 降解 宫颈疾病 |
| 英文关键词: Chirosan Membrane Degration Cervical disease |
| 基金项目: |
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| 中文摘要: |
| 目的：研究不同壳聚糖膜在体外及体内的生物降解时间。方法：用不同分子量壳聚糖为制膜材料，将4 组不同组成成分的壳
聚糖溶于1.5%乙酸中，配成1%溶液，加入辅料烘干成膜称其重量，剪成大小相等的小块，精称后放置于弱酸介质和雌鼠阴道中。
定时取样，水洗，烘干后称重,按(W-W')/W× 100 %算得降解百分率。结果：1 号较2 号降解时间快，而加入PVA的3 号与4号又较
1 号与2 号更快。结论：壳聚糖是一种生物可降解材料，壳聚糖膜的降解时间与其分子量、PVA比例、介质酸性强度等因素相关。 |
| 英文摘要: |
| Objective:To explore the vitro and vivo degradation time of chitosan films.Methods:Using chitosan with different
molecular weight as the membrane material, four groups of different compositions of chitosan dissolved in 1.5%acetic acid, Formulated
as a 1%solution, after drying and weighing adding accessories, Cut into pieces of equal size, weighed and placed in a weak acid medium
and Female rats vagina. Regular sampling, washed, dried and weighed. Calculated the percentage degradation by (W-W')/W× 100 %.Results:No.1 is faster than No.2, PVA added in the No.3 and No.4 is faster than No.1 and No.2.Conclusion:chitosan is a kind of
biodegradable material, the degradation of chitosan membrane is related to its molecular weight, PVA ratio and the acidic strength of the
mediumetc. |
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