| Objective:To evaluate the clinical efficacy of High and low-frequency subthalamic nucleus deep brain stimulation for
Parkinson’s disease (PD).Methods:31 participants with bilateral deep brain stimulation of the subthalamic nucleus were tested during
HFS for 1 month after surgery, and were tested off stimulation, during LFS, and during HFS for 6 months after surgery. The total motor
UPDRS scores, tremor, rigidity, bradykinesia and axial subscores were quantitatively examined.Results:Compared with before surgery,
HFS significantly reduced UPDRS motor scores, and tremor, rigidity, braykinesia subscores, except axial subscores, at 1 month after
surgery. When six months after surgery, the scores of the above tested items under HFS and LFS all were lower than under the OFF
condition, except axial subscores. No differences between stimulation conditions were found for those scores.Conclusion:HFS and LFS
both provided beneficial improvements in the motor function of PD, including tremor, rigidity, and bradykinesia, but didn’t demonstrate
to be effective in the treatment of axial symptoms. |
