蒋梦龙 周勇安 卢强 张志培 田丰 王艳 李小飞.CEA和CYFRA21-1 在原发性肺癌诊断中的应用价值分析[J].,2014,14(22):4280-4283 |
CEA和CYFRA21-1 在原发性肺癌诊断中的应用价值分析 |
Analysis of the Application Value of CEA and CYFRA21-1 in the Diagnosisof Primary Lung Cancer |
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DOI: |
中文关键词: 癌胚抗原 细胞角蛋白19 的片段 灵敏度 特异度 阳性预计值 肺癌 |
英文关键词: CEA CYFRA21-1 Sensitivity Specificity Positive predictive values |
基金项目:国家自然科学基金项目(30973379) |
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中文摘要: |
目的:评价血清癌胚抗原(carcinoembryonic antigen,CEA)和细胞角蛋白19 的片段(CYFRA21-1)水平对原发性肺癌的诊断价
值。方法:回顾性分析2012年5 月~2013 年5 月我科收治的329 例肺癌患者和192 例肺部良性病变患者的临床资料。结果:肺癌
患者血清CEA 或CYFRA21-1 水平随着肺癌的分期呈现逐渐上升的趋势(P<0.001,P<0.01)。以血清CEA≥ 3.4 滋g/L 作为诊断条
件诊断肺癌的灵敏度、特异度和阳性预计值预计值分别为67%、62%和75.2%;以血清CYFRA-21≥ 5.0 ug/L作为诊断条件诊断原
发性肺癌的灵敏度、特异度和阳性预计值预计值分别为48%、87%和86.3%;以血清CEA≥ 3.4 ug/L 和CYFRA-21≥ 5.0 ug/L 共同
作为诊断条件推断原发性肺癌的灵敏度、特异度和阳性预计值预计值分别为48%、87%和86.3%;良性肺部疾病患者中血清CEA
和CYFRA-21 水平同时升高者只有2%。结论:血清CEA≥ 3.4 ug/L 和CYFRA-21≥ 5.0 ug/L 同时升高对肺癌有具有重要的诊断
价值,可有效的鉴别原发性肺癌与其它良性病变。 |
英文摘要: |
Objective:Assess diagnostic value of CEA and CYFRA21-1 in primary lung cancer.Methods:A retrospective analysis
was conducted on 329 patients treated for lung cancer and 192 patients treated for benign lung disease between May 2012 and May 2013.Results:The serum levels of CEA and CYFRA21-1 showed a tendency to be increased in the more advanced stages of lung cancer. Sensitivity,
specificity and positive predictive values of CEA in the diagnosis of primary lung cancer was 67%, 62% and 75.2 % using 3.2
ug/L as the cut-off level, respectively. Sensitivity, specificity and positive predictive values of CYFRA21-1 in the diagnosis of primary
lung cancer was 48%, 87%and 86.3%using 5.0 ug/L as the cut-off level, respectively. Sensitivity, specificity and positive predictive values
with the combination of positive CEA and positive CYFRA 21-1 in the diagnosis of primary lung cancer was 13%, 98% and 91.3%
using the cut-off level, respectively. The combination of positive CEA and positive CYFRA21-1 at the cut-off level in the benign disease
was only 2%.Conclusion:Combining CEA and CYFRA 21-1 are reliable serum tumor markers for the diagnosis of lung cancer, if the
prevalent rate of patients is high, are helpful to distinguish primary lung cancer frombenign lung disease. |
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