| ABSTRACT:Granulysin play an important role of several cells or tissues which refer to the cytolytic and antimicrobial function,
including tumor cells, bacteria and the fungi and parasites. Granulysin is also a chemoattractant for T lymphocytes, monocytes and other
inflammatory cells and activates the expression of a number of cytokines, including regulated upon activation T cell expressed and
secreted (RANTES), monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage inflammatory protein (MIP)-1a, interleukin (IL)
-10, IL-1, IL-6 and interferon (IFN)-a. It is indicated that the Granulysin might be in a lot of diseases such as the infection, cancer,
transplantation, autoimmunity, skin and reproductive maladies. Based on the particle lysin versatility, this essay aims to discuss and sum
up the mechanismof action and relation to clinical common diseases |
