| 宋维玲杜建新△ 崔高杰邱丽丽薛超.VEGF、组织因子及D- 二聚体与肺癌关系的研究*[J].,2014,14(20):3888-3890 |
| VEGF、组织因子及D- 二聚体与肺癌关系的研究* |
| Research on the Relationship among VEGF, Tissue Factor,D-Dimer and Lung Cancer* |
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| DOI： |
| 中文关键词: 肺癌 VEGF TF D-二聚体 静脉血栓 |
| 英文关键词: Lung cancer VEGF TF D-Dimer VTE |
| 基金项目:青岛市科技局资助项目（09-2-2-3-msh-5） |
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| 中文摘要: |
| 摘要目的：探讨肺癌患者血浆VEGF、组织因子及D-二聚体水平与并发静脉血栓的关系及其相关性。方法：收集2013 年3 月至
2013 年9 月，青岛大学附属医院收治的初诊肺癌患者83 例为肺癌组，肺癌并静脉栓塞组11 例，健康体检组80 例，应用酶联免疫
吸附(ELISA)法测定VEGF、TF、D- 二聚体的水平并进行比较分析。结果：肺癌组和肺癌并静脉栓塞组血浆VEGF、TF 及D- 二聚
体水平均高于健康对照组，肺癌并静脉栓塞组血浆VEGF、TF及D-二聚体水平高于肺癌组，VEGF 与TF 及D-二聚体的表达呈
正相关。结论：VEGF、TF及D-二聚体是肺癌患者并发静脉血栓的重要标志物，可通过测定其在肺癌患者血浆中的水平来推测并
发静脉血栓的危险性，以针对性应用抗凝治疗。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the relationship among boold levels of vascular endothelial growth factor (VEGF), tissue
factor (TF), D-Dimer and thromboembolic events in patients with lung cancer. Methods:From March to September 2013, 83 cases of the
first diagnosis lung cancer patients of the affiliated hospital of Qingdao University were collected as lung cancer group, 11 lung cancer
patients accompanied with venous thromboembolism (VTE) as lung cancer with VTE group and 80 normal healthy as controls. VEGF,
TF and D-Dimer levels in serum were detected by enzyme-linked immunosorbent assay (ELISA). The correlation among VEGF, TF,
D-Dimer and lung cancer was analyzed. Results:VEGF, TF and D-Dimer levels in serumof lung cancer group and lung cancer with VTE
group were significantly higher than that in normal control group (P＜0.05). VEGF, TF and D-Dimer levels of lung cancer with VTE
group were observably higher than that in lung cancer group (P＜0.05) . The expression of VEGF and TF and D-Dimer was positively
correlation in lung cancer with VTE patients. Conclusion:VEGF, TF and D-Dimer are important marks of lung cancer patients
accompanied with thromboembolism events. The risk of venous thrombosis of lung cancer patients can be evaluated by measuring the
levels of VEGF, TF and D-Dimer, in order to applicate anticoagulant therapy pertinently. |
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