| 周俊梅 韦芳 刘苗苗 张必萌.肿瘤酸性微环境的研究进展[J].,2014,14(19):3775-3778 |
| 肿瘤酸性微环境的研究进展 |
| Process in the Research of Acidic Microenvironments and Tumor Metastasis |
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| DOI： |
| 中文关键词: 酸性微环境 pH 肿瘤转移 综述 |
| 英文关键词: Acidic Microenvironments pH Tumor metastasis Review |
| 基金项目:上海市科委实验动物专项（11140900902） |
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| 中文摘要: |
| 研究表明，肿瘤转移是恶性肿瘤的临床治疗失败的根本原因。肿瘤转移不仅取决于肿瘤细胞自身的特性，还涉及其与肿瘤
酸性微环境之间的相互作用。肿瘤微环境构成非常复杂，可促进肿瘤的增生、转移、侵袭，以及逃避宿主免疫监视和治疗耐药性。
肿瘤细胞的生存依赖于在酸性微环境条件下的适应，肿瘤细胞可以通过一些离子交换体维持酸性微环境，缺氧的肿瘤组织酸化
可以释放蛋白酶如纤维蛋白酶及MMPs 降解细胞外基质、上调VEGF 基因表达促进肿瘤新生血管生成等促进肿瘤侵袭转移。近
年来，影响肿瘤微环境的因素已经成为癌症研究领域中的新兴话题。 |
| 英文摘要: |
| The study showed that tumor metastasis is the root cause of failure in the clinical treatment. Nevertheless, Tumor
metastasis, not only depends on the characteristics of the tumor cells themselves, but also relates to the interaction between the tumor
cells and their acidic microenvironment. The tumor microenvironment (TME) consists of tumor cells that can promote neoplastic
transformation, support tumor growth and invasion, protect the tumor from host immunity, foster therapeutic resistance. Tumor cell
survival relies upon adaptation to the acidic conditions of the tumor microenvironment. Tumor cells through some ion permutoid such as
NHE and VHA maintain acid microenvironment. This effects of hypoxic and acidic exposure through the action of proteinase such as
plasmin or MMPs, as well as up-expression of VEGF gene increase the invasive and metastatic efficiency. In recent years, its cellular and
molecular components, and how they can affect neoplastic progression, has become an emerging topic in cancer research. |
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