| 钱铁镛 姚伟峰 陈一丁 王雯 王卓平.alpha-硫辛酸对2 型糖尿病早期肾病的保护作用研究[J].,2014,14(19):3663-3665 |
| alpha-硫辛酸对2 型糖尿病早期肾病的保护作用研究 |
| The Study of the Protective Effects of the Injection of alpha-Lipoic Acid on Type2 Early Diabetes Nephropathy |
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| DOI： |
| 中文关键词: 2 型糖尿病 早期肾病 alpha－硫辛酸 抗氧化剂 并发症 |
| 英文关键词: Type 2 diabetes Early nephropathy alpha-lipoic acid Antioxidants Complications |
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| 中文摘要: |
| 目的：探讨注射用alpha-硫辛酸对2 型糖尿病早期肾病（DN）的保护作用。方法：将56 例2 型糖尿病早期肾病患者随机分为治
疗组28 例，采用注射alpha-硫辛酸加常规治疗；对照组28 例，仅给予常规治疗。治疗前后测定尿微量白蛋白排泄率（UAER）、超氧化
物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）水平。结果：与治疗前比较，治疗组UAER及MDA均显著降低（P＜0.05），SCr、
SOD及NO 显著升高（P＜0.05）。对照组SCr、UAER、SOD、MDA 及NO与治疗前比较差异无统计学意义（P＞0.05）。结论：注射用
alpha-硫辛酸能减少2型糖尿病肾病患者尿微量白蛋白的排泄，对早期肾病具有保护作用。 |
| 英文摘要: |
| Objective:To study the protective effects of the injection of alpha-lipoic acid on type 2 early diabetes nephropathy (DN).Methods:56 cases of early nephropathy in type 2 diabetes patients are randomly divided into treatment group 28 cases, use alpha-lipoic acid
injection and conventional therapy; control group of 28 patients receive only conventional treatment. The urinary albumin excretion rate
(UAER), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) levels are measured before and after treatment.Results:Compared with prior treatment, the UAER and MDA of treated group are significantly reduced (P<0.05), SCr, SOD and NO
were significantly increased (P<0.05). The comparative difference between SCr, UAER, SOD, MDA and NO of Control group and
before treatment has no statistical significance (P>0.05).Conclusion:Injection alpha-lipoic acid can reduce type 2 diabetic patients with
nephropathy urinary albumin excretion, has a protective effect on early kidney disease. |
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