| 梅玉霞 庄承 李远光 刘小敏 傅伟.温抗体型自身免疫性溶血性贫血的诊治进展[J].,2014,14(18):3575-3577 |
| 温抗体型自身免疫性溶血性贫血的诊治进展 |
| Diagnosis and Treatment of WarmAntibody Autoimmune Hemolytic Anemia |
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| DOI： |
| 中文关键词: 自身免疫性溶血性贫血 温抗体 发病机制 治疗方法 |
| 英文关键词: Autoimmune hemolytic anemia Warmantibodies Pathogenesis Therapies |
| 基金项目: |
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| 中文摘要: |
| 自身免疫性溶血性贫血（AIHI）按照自身抗体作用于红细胞时所需的温度分为温抗体型AIHI（WAIHI）和冷抗体型AIHI
（CAIHI），以WAIHI居多，并且多为继发性。WAIHI的发病与温度没有显著的相关关系，其发病是由各种原因引起的免疫机制变
异，主要包括基因遗传因素、自身免疫调节异常及免疫因素等，导致针对自身红细胞的抗体产生，再与红细胞膜表面抗原结合，它
是一种会使自身红细胞破坏或者缩短寿命的比较难以治疗的贫血，目前治疗AIHI 首选疗法为肾上腺皮质激素(激素)，有效率可
达80%，大剂量静脉注射丙种球蛋白（IVIG）、输血、切除脾等方法的使用也在实践中逐渐增多，并且疗效可观。近年来对温抗体型
自身免疫性溶血性贫血的诊治进展的研究越来越多。 |
| 英文摘要: |
| Autoimmune hemolytic anemia (AIHI) can be divided into WAIHIand CAIHI, according to the temperature of
autoantibodies, it is in the majority with WAIHI, moreover, most of them are secondary. Clinical symptoms and laboratory performance
including basic diseases. The onset of WAIHI that there was no significant correlation with temperature. The disease is caused by a
variety of reasons the immune mechanism of the variation . Its etiology includes genetic factors, immune dysregulation, immune factors
and so on. Whan makes antibodies against their red blood cells, and the red cell membrane surface antigen, it tends to make itself a kind
of red blood cell destruction or life shorten, it is a anemia difficult to be treated. The current treatments of AIHI preferred therapy for
adrenal cortical hormone (hormones). The preferred treatments for AIHI is adrenal cortical hormone (hormones), the efficient can reach a
high level at 80%. The use of High-dose intravenous gamma globulin, blood transfusion, removal of the spleen are on the rise, and the
effect is considerable. In recent years, there are more and more research about the treatment of warmautoimmune hemolytic anemia. |
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