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目的：探讨老年高血压合并2 型糖尿病患者血清同型半胱氨酸（Homocysteine, Hcy）、血尿酸（Serum uric acid, SUA）水平变化及其临床意义。方法：2012 年9 月至2013 年9 月期间，我院诊治的40 例单纯高血压和40 例高血压合并2 型糖尿病患者，分别作为对照组和研究组，检测两组血清Hcy、SUA水平。结果：两组患者收缩压、舒张压比较无统计学差异（P>0.05）。研究组空腹血糖、餐后2h 血糖、血清Hcy、SUA 均显著高于对照组（P<0.05）。研究组中血管并发症患者血清Hcy、SUA为（25.0± 5.0）umol/L 和（390.0± 65.0）mmol/L显著高于无血管并发症患者（17.0± 4.0）umol/L 和（330.0± 55.0）mmol/L，血管并发症患者FBG、餐后2h 血糖与无血管并发症患者比较无统计学差异（P>0.05）。结论：高血压合并2 型糖尿病患者血清Hcy、SUA异常升高，且存在慢性血管并发症患者两者水平更高，血清Hcy、SUA是老年高血压合并2 型糖尿病的危险因素。

英文摘要:

Objective:To study the levels change and relationship of serum homocysteine (Hcy) and uric acid (UA) for old patients with hypertension and type 2 diabetes.Methods:The 40 patients with hypertension and 40 patients with hypertension and type 2 diabetes in our hospital during the period from Sep 2012 to Sep 2013 were regarded as the subjects of the control group and the study group. The levels of serum homocysteine and uric acid in the two groups and the relationship were measured and compared.Results:The systolic blood pressure, diastolic blood pressure of two groups was not statistically significant (P>0.05). In study group, fasting blood glucose, 2h postprandial blood glucose, serum Hcy, SUA were significantly higher than those in the control group (P<0.05). To observe the vascular complications in patients serum Hcy, SUA were （25.0± 5.0）umol/L and （390.0± 65.0）mmol/L significantly higher than that（17.0± 4.0）umol/L and（330.0± 55.0）mmol/L of patients without vascular complications, there were no statistical differences in 2h glucose, FBG postprandial vascular complications in patients with and without vascular complications in patients with (P>0.05).Conclusion:The serumhomocysteine and uric acid are the risk factors for old patients with hypertension and type 2 diabetes

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