| 郝菲 张慧娟 俞秋霞 白盟盟 牟佳威.Chemerin 及ChemR23 与糖尿病大血管病变[J].,2014,14(16):3198-3200 |
| Chemerin 及ChemR23 与糖尿病大血管病变 |
| Chemerin/ChemR23 and Macroangiopathy in Diabetes |
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| DOI： |
| 中文关键词: Chemerin ChemR23 糖尿病 大血管病变 |
| 英文关键词: Chemerin ChemR23 Diabetes Macroangiopathy |
| 基金项目: |
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| 中文摘要: |
| Chemerin 是2007 年新确认的一种脂肪因子，其主要功能受体为ChemR23。近期研究发现chemerin 可能是联系肥胖、糖尿
病及动脉粥样硬化的潜在因子，有望为糖尿病及其血管并发症的预防及治疗提供新的靶点。然而，chemerin 及其受体ChemR23
参与糖尿病及其大血管病变的具体机制尚不明确。本文将就目前研究中chemerin 及其受体ChemR23 与糖尿病及其大血管病变
的关系作一综述，并从免疫及炎症反应、氧化应激、自噬、糖脂代谢和胰岛素抵抗等方面，分析chemerin 分别对巨噬细胞、血管内
皮细胞、脂肪细胞及骨骼肌细胞的影响，从而进一步阐述chemerin 及其受体ChemR23 参与糖尿病及其大血管病变的具体生物学
机制。 |
| 英文摘要: |
| Chemerin is a novel adipokine, which is identified in 2007. Its main functional receptor is ChemR23. Recent studies
have found that chemerin may be a potential factor linked to obesity, diabetes and atherosclerosis, so it is expected to provide a new
target for the prevention and treatment of diabetes and its vascular complications. However, the specific mechanism for chemerin and its
receptor ChemR23 involving in diabetes and its vascular complications is not clear so far. This review summarizes the recent findings on
the relationship of chemerin/ChemR23 and macroangiopathy in diabetes. Besides, we analysis the role of chemerin on macrophages,
endothelial cells, adipocytes and skeletal muscle cells, involving in immune response, inflammation, oxidative stress, autophagy,
glycolipid metabolismand insulin resistance to elaborate the related mechanisms. |
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